https://github.com/althonos/muscle
Multiple sequence alignment with top benchmark scores scalable to thousands of sequences. Generates replicate alignments, enabling assessment of downstream analyses such as trees and predicted structures.
Science Score: 23.0%
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Low similarity (5.4%) to scientific vocabulary
Last synced: 9 months ago
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Multiple sequence alignment with top benchmark scores scalable to thousands of sequences. Generates replicate alignments, enabling assessment of downstream analyses such as trees and predicted structures.
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Fork of rcedgar/muscle
Created about 4 years ago
· Last pushed about 4 years ago
https://github.com/althonos/muscle/blob/main/
 MUSCLE is widely-used software for making multiple alignments of biological sequences. Version 5 of MUSCLE achieves highest scores on Balibase, Bralibase and Balifam benchmark tests and scales to thousands of sequences on a commodity desktop computer. This version supports generating an ensemble of alternative alignments with the same high accuracy obtained with default parameters. By comparing downstream predictions from different alignments, such as trees, a biologist can evaluation the robustness of conclusions against alignment errors. ### Downloads Binary files are self-contained, no dependencies. https://github.com/rcedgar/muscle/releases ### Documentation [Muscle v5 home page](https://drive5.com/muscle5) [Manual](https://drive5.com/muscle5/manual) ### Building MUSCLE from source [https://github.com/rcedgar/muscle/wiki/Building-MUSCLE](https://github.com/rcedgar/muscle/wiki/Building-MUSCLE) ### Reference R.C. Edgar (2021) "MUSCLE v5 enables improved estimates of phylogenetic tree confidence by ensemble bootstrapping" [https://www.biorxiv.org/content/10.1101/2021.06.20.449169v1.full.pdf](https://www.biorxiv.org/content/10.1101/2021.06.20.449169v1.full.pdf)
Owner
- Name: Martin Larralde
- Login: althonos
- Kind: user
- Location: Heidelberg, Germany
- Company: EMBL / LUMC, @zellerlab
- Twitter: althonos
- Repositories: 91
- Profile: https://github.com/althonos
PhD candidate in Bioinformatics, passionate about programming, SIMD-enthusiast, Pythonista, Rustacean. I write poems, and sometimes they are executable.