https://github.com/csinva/axon-ap-propagation
Code for simulations of action potential propagation
Science Score: 23.0%
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○CITATION.cff file
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✓codemeta.json file
Found codemeta.json file -
○.zenodo.json file
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○DOI references
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○Academic publication links
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✓Committers with academic emails
1 of 1 committers (100.0%) from academic institutions -
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○Scientific vocabulary similarity
Low similarity (5.0%) to scientific vocabulary
Keywords
action-potential
axon
neuron-simulations
neuroscience
simulation
Last synced: 10 months ago
·
JSON representation
Repository
Code for simulations of action potential propagation
Basic Info
- Host: GitHub
- Owner: csinva
- Language: AMPL
- Default Branch: master
- Size: 7.56 MB
Statistics
- Stars: 1
- Watchers: 3
- Forks: 1
- Open Issues: 0
- Releases: 0
Topics
action-potential
axon
neuron-simulations
neuroscience
simulation
Created over 9 years ago
· Last pushed about 9 years ago
Metadata Files
Readme
README.md
axon simulations
- tapering axon simulation code based on Johnson, Holmes, Brown, and Jung 2015
setup
run the code
- clone the repo
- compile the mod files (differs based on OS - see NEURON documentation)
- run main.hoc
todo
reference
goals
- maximize velocity
- minimize energy
- minimize noise variability
constraints
- amount of protein membrane can sustain
hypotheses
- node only gets to minimum needed
- see brill et al ~1997
- Resting potential might be getting messed up
- Look at changing gbar
- Look at changing potassium conductances
notes
- currently fires with noise
- fires at very low voltage
- Johnson, Holmes, Brown, and Jung 2015
- Goal: maximize conduction velocity but minimize metabolic costs
- Myelination does this by decreasing capacitance
- Increasing axon diameter does this by increasing ion flow
- They assume fixed number of sodium channels and change morphology
- 3 different taperings along the PARA
- other papers
- base on Mcintyre, Richardson, and Grill 2001
- empirical fits to blight, 1985 rat recording and david, 1995 rat recording
done
- fixed surface area and looked at different diameters
Owner
- Name: Chandan Singh
- Login: csinva
- Kind: user
- Location: Microsoft research
- Company: Senior researcher
- Website: csinva.io
- Twitter: csinva_
- Repositories: 29
- Profile: https://github.com/csinva
Senior researcher @Microsoft interpreting ML models in science and medicine. PhD from UC Berkeley.
GitHub Events
Total
Last Year
Committers
Last synced: about 1 year ago
Top Committers
| Name | Commits | |
|---|---|---|
| Chandan | c****q@v****u | 35 |
Committer Domains (Top 20 + Academic)
virginia.edu: 1
Issues and Pull Requests
Last synced: about 1 year ago
All Time
- Total issues: 0
- Total pull requests: 0
- Average time to close issues: N/A
- Average time to close pull requests: N/A
- Total issue authors: 0
- Total pull request authors: 0
- Average comments per issue: 0
- Average comments per pull request: 0
- Merged pull requests: 0
- Bot issues: 0
- Bot pull requests: 0
Past Year
- Issues: 0
- Pull requests: 0
- Average time to close issues: N/A
- Average time to close pull requests: N/A
- Issue authors: 0
- Pull request authors: 0
- Average comments per issue: 0
- Average comments per pull request: 0
- Merged pull requests: 0
- Bot issues: 0
- Bot pull requests: 0