ontogpt
LLM-based ontological extraction tools, including SPIRES
Science Score: 77.0%
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✓DOI references
Found 4 DOI reference(s) in README -
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5 of 29 committers (17.2%) from academic institutions -
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○Scientific vocabulary similarity
Low similarity (16.5%) to scientific vocabulary
Keywords
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Repository
LLM-based ontological extraction tools, including SPIRES
Basic Info
- Host: GitHub
- Owner: monarch-initiative
- License: bsd-3-clause
- Language: Jupyter Notebook
- Default Branch: main
- Homepage: https://monarch-initiative.github.io/ontogpt/
- Size: 81.6 MB
Statistics
- Stars: 720
- Watchers: 18
- Forks: 98
- Open Issues: 74
- Releases: 50
Topics
Metadata Files
README.md
OntoGPT

Introduction
OntoGPT is a Python package for extracting structured information from text with large language models (LLMs), instruction prompts, and ontology-based grounding.
For more details, please see the full documentation.
Quick Start
OntoGPT runs on the command line, though there's also a minimal web app interface (see Web Application section below).
- Ensure you have Python 3.9 or greater installed.
Install with
pip:bash pip install ontogptSet your OpenAI API key:
bash runoak set-apikey -e openai <your openai api key>See the list of all OntoGPT commands:
bash ontogpt --helpTry a simple example of information extraction:
bash echo "One treatment for high blood pressure is carvedilol." > example.txt ontogpt extract -i example.txt -t drugOntoGPT will retrieve the necessary ontologies and output results to the command line. Your output will provide all extracted objects under the heading
extracted_object.
Web Application
There is a bare bones web application for running OntoGPT and viewing results.
First, install the required dependencies with pip by running the following command:
bash
pip install ontogpt[web]
Then run this command to start the web application:
bash
web-ontogpt
NOTE: We do not recommend hosting this webapp publicly without authentication.
Model APIs
OntoGPT uses the litellm package (https://litellm.vercel.app/) to interface with LLMs.
This means most APIs are supported, including OpenAI, Azure, Anthropic, Mistral, Replicate, and beyond.
The model name to use may be found from the command ontogpt list-models - use the name in the first column with the --model option.
In most cases, this will require setting the API key for a particular service as above:
bash
runoak set-apikey -e anthropic-key <your anthropic api key>
Some endpoints, such as OpenAI models through Azure, require setting additional details. These may be set similarly:
bash
runoak set-apikey -e azure-key <your azure api key>
runoak set-apikey -e azure-base <your azure endpoint url>
runoak set-apikey -e azure-version <your azure api version, e.g. "2023-05-15">
These details may also be set as environment variables as follows:
bash
export AZURE_API_KEY="my-azure-api-key"
export AZURE_API_BASE="https://example-endpoint.openai.azure.com"
export AZURE_API_VERSION="2023-05-15"
Open Models
Open LLMs may be retrieved and run through the ollama package (https://ollama.com/).
You will need to install ollama (see the GitHub repo), and you may need to start it as a service with a command like ollama serve or sudo systemctl start ollama.
Then retrieve a model with ollama pull <modelname>, e.g., ollama pull llama3.
The model may then be used in OntoGPT by prefixing its name with ollama/, e.g., ollama/llama3, along with the --model option.
Some ollama models may not be listed in ontogpt list-models but the full list of downloaded LLMs can be seen with ollama list command.
Evaluations
OntoGPT's functions have been evaluated on test data. Please see the full documentation for details on these evaluations and how to reproduce them.
Related Projects
- TALISMAN, a tool for generating summaries of functions enriched within a gene set. TALISMAN uses OntoGPT to work with LLMs.
Tutorials and Presentations
- Presentation: "Staying grounded: assembling structured biological knowledge with help from large language models" - presented by Harry Caufield as part of the AgBioData Consortium webinar series (September 2023)
- Presentation: "Transforming unstructured biomedical texts with large language models" - presented by Harry Caufield as part of the BOSC track at ISMB/ECCB 2023 (July 2023)
- Presentation: "OntoGPT: A framework for working with ontologies and large language models" - talk by Chris Mungall at Joint Food Ontology Workgroup (May 2023)
Citation
The information extraction approach used in OntoGPT, SPIRES, is described further in: Caufield JH, Hegde H, Emonet V, Harris NL, Joachimiak MP, Matentzoglu N, et al. Structured prompt interrogation and recursive extraction of semantics (SPIRES): A method for populating knowledge bases using zero-shot learning. Bioinformatics, Volume 40, Issue 3, March 2024, btae104, https://doi.org/10.1093/bioinformatics/btae104.
Acknowledgements
This project is part of the Monarch Initiative. We also gratefully acknowledge Bosch Research for their support of this research project.
Owner
- Name: Monarch Initiative
- Login: monarch-initiative
- Kind: organization
- Location: Globally-distributed team (see https://monarchinitiative.org/page/team)
- Website: https://github.com/monarch-initiative/monarch-app/blob/master/README.md#about-monarch
- Repositories: 118
- Profile: https://github.com/monarch-initiative
Cross-species disease discovery and diagnosis
Citation (CITATION.cff)
cff-version: 1.2.0
message: "If you use OntoGPT, please cite it as follows."
authors:
- family-names: "Caufield"
given-names: "J. Harry"
orcid: "https://orcid.org/0000-0001-5705-7831"
- family-names: "Hegde"
given-names: "Harshad"
orcid: "https://orcid.org/0000-0002-2411-565X"
- family-names: "Emonet"
given-names: "Vincent"
orcid: "https://orcid.org/0000-0002-1501-1082"
- family-names: "Harris"
given-names: "Nomi L."
orcid: "https://orcid.org/0000-0001-6315-3707"
- family-names: "Joachimiak"
given-names: "Marcin P."
orcid: "https://orcid.org/0000-0001-8175-045X"
- family-names: "Matentzoglu"
given-names: "Nicolas"
orcid: "https://orcid.org/0000-0002-7356-1779"
- family-names: "Kim"
given-names: "HyeongSik"
orcid: "https://orcid.org/0000-0002-3002-9838"
- family-names: "Moxon"
given-names: "Sierra A.T."
orcid: "https://orcid.org/0000-0002-8719-7760"
- family-names: "Reese"
given-names: "Justin T."
orcid: "https://orcid.org/0000-0002-2170-2250"
- family-names: "Haendel"
given-names: "Melissa A."
orcid: "https://orcid.org/0000-0001-9114-8737"
- family-names: "Robinson"
given-names: "Peter N."
orcid: "https://orcid.org/0000-0002-0736-9199"
- family-names: "Mungall"
given-names: "Christopher J."
orcid: "https://orcid.org/0000-0002-6601-2165"
title: "OntoGPT"
version: 0.3.8
date-released: 2024-02-08
url: "https://github.com/monarch-initiative/ontogpt"
doi: 10.5281/zenodo.7894107
preferred-citation:
type: article
authors:
- family-names: "Caufield"
given-names: "J. Harry"
orcid: "https://orcid.org/0000-0001-5705-7831"
- family-names: "Hegde"
given-names: "Harshad"
orcid: "https://orcid.org/0000-0002-2411-565X"
- family-names: "Emonet"
given-names: "Vincent"
orcid: "https://orcid.org/0000-0002-1501-1082"
- family-names: "Harris"
given-names: "Nomi L."
orcid: "https://orcid.org/0000-0001-6315-3707"
- family-names: "Joachimiak"
given-names: "Marcin P."
orcid: "https://orcid.org/0000-0001-8175-045X"
- family-names: "Matentzoglu"
given-names: "Nicolas"
orcid: "https://orcid.org/0000-0002-7356-1779"
- family-names: "Kim"
given-names: "HyeongSik"
orcid: "https://orcid.org/0000-0002-3002-9838"
- family-names: "Moxon"
given-names: "Sierra A.T."
orcid: "https://orcid.org/0000-0002-8719-7760"
- family-names: "Reese"
given-names: "Justin T."
orcid: "https://orcid.org/0000-0002-2170-2250"
- family-names: "Haendel"
given-names: "Melissa A."
orcid: "https://orcid.org/0000-0001-9114-8737"
- family-names: "Robinson"
given-names: "Peter N."
orcid: "https://orcid.org/0000-0002-0736-9199"
- family-names: "Mungall"
given-names: "Christopher J."
orcid: "https://orcid.org/0000-0002-6601-2165"
doi: "10.1093/bioinformatics/btae104"
journal: "Bioinformatics"
title: "Structured Prompt Interrogation and Recursive Extraction of Semantics (SPIRES): a method for populating knowledge bases using zero-shot learning"
year: 2024
url: https://doi.org/10.1093/bioinformatics/btae104
GitHub Events
Total
- Create event: 40
- Commit comment event: 2
- Release event: 8
- Issues event: 44
- Watch event: 119
- Delete event: 29
- Issue comment event: 81
- Push event: 114
- Pull request review comment event: 1
- Pull request review event: 2
- Pull request event: 67
- Fork event: 18
Last Year
- Create event: 40
- Commit comment event: 2
- Release event: 8
- Issues event: 44
- Watch event: 119
- Delete event: 29
- Issue comment event: 81
- Push event: 114
- Pull request review comment event: 1
- Pull request review event: 2
- Pull request event: 67
- Fork event: 18
Committers
Last synced: 9 months ago
Top Committers
| Name | Commits | |
|---|---|---|
| caufieldjh | j****d@g****m | 1,318 |
| cmungall | c****m@b****g | 112 |
| Harshad Hegde | h****b@g****m | 41 |
| Justin Reese | j****e@g****m | 39 |
| AgranyaGitHub | a****4@g****m | 38 |
| Bill Duncan | w****n | 16 |
| marcin p. joachimiak | 4****n | 14 |
| Agranya Ketha | a****3@b****u | 9 |
| Yaroslav Halchenko | d****n@o****m | 6 |
| Krishna Chaitanya Bandi | 9****i | 6 |
| diatomsRcool | a****n@g****m | 5 |
| Nomi Harris | n****s | 3 |
| SLotreck | l****s@m****u | 3 |
| Sierra Taylor Moxon | s****r@g****m | 3 |
| Jim Balhoff | j****m@b****g | 2 |
| Nico Matentzoglu | n****u@g****m | 2 |
| Sujay Patil | s****l@g****m | 2 |
| Leonardo local Kubuntu 22.04 | l****4@g****m | 2 |
| Andrew Su | a****u@s****u | 1 |
| Daiki Sakai | 1****d | 1 |
| Daniel Bauer | d****r@s****e | 1 |
| Gabe Reder | g****r@g****m | 1 |
| Justin Reese | j****b@g****m | 1 |
| Mark A. Miller | M****M@l****v | 1 |
| Patrick Kalita | p****a@l****v | 1 |
| Tyler T. Procko | 3****0 | 1 |
| Patrick Golden | p****n@e****m | 1 |
| Vincent Emonet | v****t@g****m | 1 |
| unknown | t****k@g****m | 1 |
Committer Domains (Top 20 + Academic)
Issues and Pull Requests
Last synced: 6 months ago
All Time
- Total issues: 206
- Total pull requests: 239
- Average time to close issues: 2 months
- Average time to close pull requests: 8 days
- Total issue authors: 49
- Total pull request authors: 20
- Average comments per issue: 1.94
- Average comments per pull request: 0.84
- Merged pull requests: 221
- Bot issues: 0
- Bot pull requests: 0
Past Year
- Issues: 34
- Pull requests: 63
- Average time to close issues: 9 days
- Average time to close pull requests: 1 day
- Issue authors: 13
- Pull request authors: 6
- Average comments per issue: 1.06
- Average comments per pull request: 0.56
- Merged pull requests: 56
- Bot issues: 0
- Bot pull requests: 0
Top Authors
Issue Authors
- caufieldjh (107)
- cmungall (8)
- serenalotreck (5)
- kluo9 (4)
- yy20716 (4)
- timalamenciak (3)
- rebeccaito (3)
- vemonet (3)
- peiyaoli (3)
- justaddcoffee (3)
- dosumis (3)
- nlharris (3)
- kevinschaper (3)
- Vishal-Joshi (2)
- lzt5269 (2)
Pull Request Authors
- caufieldjh (266)
- cmungall (26)
- realmarcin (8)
- justaddcoffee (5)
- serenalotreck (4)
- hrshdhgd (4)
- leokim-l (2)
- yarikoptic (2)
- ptgolden (2)
- nlharris (2)
- dnlbauer (2)
- gkreder (2)
- timalamenciak (2)
- k-bandi (2)
- andrewsu (1)
Top Labels
Issue Labels
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Packages
- Total packages: 1
-
Total downloads:
- pypi 791 last-month
- Total dependent packages: 0
- Total dependent repositories: 1
- Total versions: 48
- Total maintainers: 3
pypi.org: ontogpt
OntoGPT is a Python package for extracting structured information from text with large language models (LLMs), instruction prompts, and ontology-based grounding.
- Documentation: https://ontogpt.readthedocs.io/
- License: BSD-3
-
Latest release: 1.0.17
published 6 months ago
Rankings
Maintainers (3)
Dependencies
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- actions/checkout v3.0.2 composite
- actions/setup-python v4 composite
- snok/install-poetry v1.3.1 composite
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