tsdate - 0.2.3

Minor release to ensure dated nodes are spaced out enough to place mutations

- Python
Published by hyanwong 9 months ago

tsdate - 0.2.2

Features

• An allow_unary flag (False by default) has been added to all methods.

• A set_metadata flag has been added so that node and mutation metadata can be omitted, saved (default), or overwritten even if this requires changing the schema.

• An environment variable TSDATE_ENABLE_NUMBA_CACHE can be set to cache JIT compiled code, speeding up loading time (useful when testing).

• The time taken for running tsdate is now recorded in the provenance data

• Historical samples (sample nodes with time > 0) are now allowed in the tree sequence.

Documentation

• Various fixes in documentation, including documenting returned fits.

Breaking changes

• The return_posteriors argument has been removed and replaced with return_fit. An instance of one of two previously internal classes, ExpectationPropagation and BeliefPropagation, are now returned when return_fit=True, and posteriors can be obtained using fit.node_posteriors().

• Topology-only dating (setting mutation_rate=None) has been removed for tree sequences of more than one tree, as tests have found that span-weighting the conditional coalescent causes substantial bias.

• The trim_telomeres parameter in the tsdate.preprocess_ts() function has been renamed to erase_flanks, to match tinfer.preprocess(). The previous name is kept as a deprecated alias.

- Python
Published by hyanwong 11 months ago

tsdate - 0.2.1

Bugfixes

• Minor bug fixed with final step of algorithm (path rescaling).

Features

• Initial support for dating with unphased (or poorly phased) singleton mutations via singletons_phased=False option. The API is preliminary and may change.

Documentation

• Fixed description of priors for variational gamma method, which were referred to a 'flat' or improper but are actually empirical Bayes priors on root node ages, fit by expectation maximization.

- Python
Published by hyanwong over 1 year ago

tsdate - 0.2.0

Bugfixes

• Variational gamma uses a rescaling approach which helps considerably if e.g. population sizes vary over time

• Variational gamma does not use mutational area of branches, but average path length, which reduces bias in tree sequences containing polytomies

Breaking changes

• The default method has been changed to variational_gamma.

• Variational gamma uses an improper (flat) prior, and therefore no longer needs population_size specifying.

• The standalone preprocess_ts function also applies the split_disjoint_nodes method, which creates extra nodes but improves dating accuracy.

• Json metadata for mean time and variance in the mutation and node tables is now saved with a suitable schema. This means json.loads() is no longer needed to read it.

• The mutation_rate and population_size parameters are now keyword-only, and therefore these parameter names need to be explicitly typed out.

• The ignore-oldest option has been removed from the command-line interface, as it is no longer very helpful with new tsinfer output, which has the root node split. The option is still accessible from the Python API.

- Python
Published by benjeffery over 1 year ago

tsdate - 0.1.7

[0.1.7] - 2024-01-11

Bugfixes

• In variational gamma, Rescale messages at end of each iteration to avoid numerical instability.

- Python
Published by benjeffery about 2 years ago

tsdate - 0.1.6

[0.1.6] - 2024-01-07

Breaking changes

• The standalone preprocess_ts function now defaults to not removing unreferenced individuals, populations, or sites, aiming to change the tree sequence tables as little as possible.

• get_dates (previously undocumented) has been removed, as posteriors can be obtained using return_posterior. The normalize terminology previously used in get_dates is changed to standardize to better reflect the fact that the maximum (not sum) is one, and exposed via the outside_standardize parameter.

• The Ne argument to date has been deprecated (although it is still in the API for backward compatibility). The equivalent argument population_size should be used instead.

• The CLI -verbosity flag no longer takes a number, but uses action="count", so -v turns verbosity to INFO level, whereas -vv turns verbosity to DEBUG level.

• The return_posteriors=True option with method="inside_outside" previously returned a dict that included keys start_time and end_time, giving the impression that the posterior for node age is discretized over time slices in this algorithm. In actuality, the posterior is discretized atomically over time points, so start_time and end_time have been replaced by a single key time.

• The return_posteriors=True option with method="maximization" is no longer accepted (previously simply returned None)

• Python 3.7 is no longer supported.

Features

• A new continuous-time method, "variational_gamma" has been introduced, which uses an iterative expectation propagation approach. Tests show this increases accuracy, especially at older times. A Laplace approximation and damping are used to ensure numerical stability. After testing, the node priors used in this method are based on a global mixture prior, which can be refined during iteration. Future releases may switch to using this as the default method.

• Priors may be calculated using a piecewise-constant effective population trajectory, which is implemented in the demography.PopulationSizeHistory class. The population_size argument to date accepts either a single scalar effective population size, or a PopulationSizeHistory instance.

• Added support and wheels for Python 3.11

• The .date() function is now a wrapper for the individual dating methods (accessible using tsdate.core.dating_methods), which can be called independently. (e.g. tsdate.inside_outside(...)). This makes it easier to document method-specific options. The API docs have been revised accordingly. Provenance is now saved with the name of the method used as the celled command, rather than "command": "date".

• Major re-write of documentation (now at https://tskit.dev/tsdate/docs/), to use the standard tskit jupyterbook framework.

Bugfixes

• The returned posteriors when return_posteriors=True now return actual probabilities (scaled so that they sum to one) rather than standardized "probabilities" whose maximum value is one.

• The population size is saved in provenance metadata (as a dictionary if it is a PopulationSizeHistory instance)

• preprocess_ts always records provenance as being from the preprocess_ts command, even if no gaps are removed. The command now has a (rarely used) delete_intervals parameter, which is normally filled out and saved in provenance (as it was before). If no gap deletion is done, the param is saved as []

- Python
Published by benjeffery about 2 years ago

tsdate - 0.1.5 - Minor release

Changelog:

• Added the time_units parameter to tsdate.date, allowing users to specify the time units of the dated tree sequence. Default is "generations".

• Added the return_posteriors parameter to tsdate.date. If True, the function returns a tuple of (dated_ts, posteriors).

• mutation_rate is now a required argument in tsdate.date and tsdate.get_dates

• tsdate returns an error if users attempt to date an unsimplified tree sequence.

• Updated tsdate citation information to cite the recent Science paper

• Support for Python 3.10

- Python
Published by benjeffery over 3 years ago

tsdate - Minor feature and bugfix release

Breaking changes

• The algorithm now operates in unscaled time (in units of generations) under the hood, which means that tsdate.build_prior_grid now requires the parameter Ne.

Features

• Users now have access to the marginal posterior distributions on node age by running tsdate.get_dates, though this is undocumented for now.

Bugfixes

• A fix to the way likelihoods are added should eliminate numerical errors that are sometimes encountered when dating very large tree sequences.

- Python
Published by awohns over 4 years ago

tsdate - Support for non-contemporaneous samples, preprocessing tree sequences

Features

• Two new methods, tsdate.sites_time_from_ts and tsdate.add_sampledata_times, support inference of tree sequences from non-contemporaneous samples.
• New tutorial on inferring tree sequences from modern and historic/ancient samples explains how to use these functions in conjunction with tsinfer.
• tsdate.preprocess_ts supports dating inferred tree sequences which include large, uninformative stretches (i.e. centromeres and telomeres). Simply run this function on the tree sequence before dating it.
• ignore_outside is a new parameter in the outside pass which tells tsdate to ignore edges from oldest root (these edges are often of low quality in tsinfer inferred tree sequences)
• Development environment is now equivalent to other tskit-dev projects

- Python
Published by awohns about 5 years ago

tsdate - 0.1.2

Minor Update: UX and Traversal Path Changes

• Improve user experience with more progress bars and logging.
• Slightly change traversal method in outside and outside maximization algorithms, this should only affect inference on inferred tree sequences with large numbers of nodes at the same frequency.
• Improve reporting of current project version
• Use appdirs for default caching location
• Prevent dating tree sequences with dangling nodes

- Python
Published by awohns about 6 years ago

tsdate - Bugfix Release

Resolve bug related to storing precalculated prior file.

- Python
Published by awohns about 6 years ago

tsdate - Alpha Release

Alpha release for community testing, evaluation, and feedback.

- Python
Published by awohns about 6 years ago