hctz-model
Physiologically based pharmacokinetics (PBPK) model of hydrochlorothiazide (HCTZ)
Science Score: 49.0%
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Repository
Physiologically based pharmacokinetics (PBPK) model of hydrochlorothiazide (HCTZ)
Basic Info
- Host: GitHub
- Owner: matthiaskoenig
- Language: HTML
- Default Branch: main
- Size: 9.14 MB
Statistics
- Stars: 0
- Watchers: 1
- Forks: 0
- Open Issues: 0
- Releases: 2
Metadata Files
README.md
hctz model
This repository provides the hydrochlorothiazide physiologically based pharmacokinetics (PBPK) model.
The model is distributed as SBML available from hctz_body_flat.xml with
corresponding SBML4humans model report at https://sbml4humans.de/modelurl?url=https://raw.githubusercontent.com/matthiaskoenig/hctz-model/main/models/hctzbody_flat.xml and equations from hctz_body_flat.md.
The COMBINE archive is available from hctz_model.omex.
Comp submodels
The liver submodel is available from hctz_liver.xml with corresponding SBML4humans report at
https://sbml4humans.de/modelurl?url=https://raw.githubusercontent.com/matthiaskoenig/hctz-model/main/models/hctzliver.xml and equations from hctz_liver.md.
The kidney submodel is available from hctz_kidney.xml with corresponding SBML4humans report at
https://sbml4humans.de/modelurl?url=https://raw.githubusercontent.com/matthiaskoenig/hctz-model/main/models/hctzkidney.xml and equations from hctz_kidney.md.
The intestine submodel is available from hctz_intestine.xml with corresponding SBML4humans report at
https://sbml4humans.de/modelurl?url=https://raw.githubusercontent.com/matthiaskoenig/hctz-model/main/models/hctzintestine.xml and equations from hctz_intestine.md.
The whole-body submodel is available from hctz_body.xml with corresponding SBML4humans report at
https://sbml4humans.de/modelurl?url=https://raw.githubusercontent.com/matthiaskoenig/hctz-model/main/models/hctzbody.xml and equations from hctz_body.md.
How to cite
Lim, A., & König, M. (2025). Physiologically based pharmacokinetic (PBPK) model of hydrochlorothiazide.
Zenodo. https://doi.org/10.5281/zenodo.15427418
License
- Source Code: MIT
- Documentation: CC BY-SA 4.0
- Models: CC BY-SA 4.0
This program is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.
Funding
Matthias König was supported by the Federal Ministry of Education and Research (BMBF, Germany) within LiSyM by grant number 031L0054 and ATLAS by grant number 031L0304B and by the German Research Foundation (DFG) within the Research Unit Program FOR 5151 QuaLiPerF (Quantifying Liver Perfusion-Function Relationship in Complex Resection - A Systems Medicine Approach) by grant number 436883643 and by grant number 465194077 (Priority Programme SPP 2311, Subproject SimLivA). This work was supported by the BMBF-funded de.NBI Cloud within the German Network for Bioinformatics Infrastructure (de.NBI) (031A537B, 031A533A, 031A538A, 031A533B, 031A535A, 031A537C, 031A534A, 031A532B).
© 2024-2025 Amanda Lim & Matthias König, Systems Medicine of the Liver
Owner
- Name: Matthias König
- Login: matthiaskoenig
- Kind: user
- Location: Berlin
- Company: Humboldt University
- Website: https://livermetabolism.com
- Repositories: 146
- Profile: https://github.com/matthiaskoenig
Matthias König (PhD. in Biophysics) leads a junior research group for Systems Biology and Systems Medicine of the liver.
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Last Year
- Release event: 1
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