openfe

The Open Free Energy toolkit

https://github.com/openfreeenergy/openfe

Science Score: 67.0%

This score indicates how likely this project is to be science-related based on various indicators:

  • CITATION.cff file
    Found CITATION.cff file
  • codemeta.json file
    Found codemeta.json file
  • .zenodo.json file
    Found .zenodo.json file
  • DOI references
    Found 3 DOI reference(s) in README
  • Academic publication links
    Links to: zenodo.org
  • Committers with academic emails
  • Institutional organization owner
  • JOSS paper metadata
  • Scientific vocabulary similarity
    Low similarity (13.9%) to scientific vocabulary

Keywords

biophysics computational-chemistry free-energy free-energy-calculations molecular-dynamics
Last synced: 6 months ago · JSON representation ·

Repository

The Open Free Energy toolkit

Basic Info
  • Host: GitHub
  • Owner: OpenFreeEnergy
  • License: mit
  • Language: Python
  • Default Branch: main
  • Homepage: https://docs.openfree.energy
  • Size: 74.1 MB
Statistics
  • Stars: 190
  • Watchers: 7
  • Forks: 30
  • Open Issues: 304
  • Releases: 38
Topics
biophysics computational-chemistry free-energy free-energy-calculations molecular-dynamics
Created about 4 years ago · Last pushed 6 months ago
Metadata Files
Readme Changelog Contributing License Code of conduct Citation

README.md

Logo build coverage documentation DOI

openfe - A Python package for executing alchemical free energy calculations.

The openfe package is the flagship project of Open Free Energy, a pre competitive consortium aiming to provide robust, permissively licensed open source tools for molecular simulation in the drug discovery field.

Using openfe you can easily plan and execute alchemical free energy calculations.

See our website for more information on the project, try for yourself from the comfort of your browser, and we have documentation on using the package.

License

This library is made available under the MIT open source license.

Install

Latest release

The latest release of openfe can be installed via mamba, docker, or a single file installer. See our installation instructions for more details. Dependencies can be installed via conda through:

Development version

The development version of openfe can be installed directly from the main branch of this repository.

First install the package dependencies using mamba:

bash mamba env create -f environment.yml

The openfe library can then be installed via:

python -m pip install --no-deps .

Authors

The OpenFE development team.

Acknowledgements

OpenFE is an Open Molecular Software Foundation hosted project.

Owner

  • Name: Open Free Energy
  • Login: OpenFreeEnergy
  • Kind: organization

Citation (CITATION.cff)

cff-version: 1.2.0
message: "If you use this software, please cite it as below."
authors:
- family-names: "Alibay"
  given-names: "Irfan"
  orcid: "https://orcid.org/0000-0001-5787-9130"
- family-names: "Gowers"
  given-names: "Richard J."
  orcid: "https://orcid.org/0000-0002-3241-1846"
- family-names: "Swenson"
  given-names: "David W.H."
  orcid: "https://orcid.org/0000-0001-9922-7923"
- family-names: "Henry"
  given-names: "Michael M."
  orcid: "https://orcid.org/0000-0002-3870-9993"
- family-names: "Ries"
  given-names: "Benjamin"
  orcid: "https://orcid.org/0000-0002-0945-8304"
- family-names: "Baumann"
  given-names: "Hannah M."
  orcid: "https://orcid.org/0000-0002-1736-7744"
- family-names: "Eastwood"
  given-names: "James R. B."
  orcid: "https://orcid.org/0000-0003-3895-5227"
- given-names: "Joshua A."
  family-names: "Mitchell"
  orcid: 'https://orcid.org/0000-0002-8246-5113'
- given-names: "David"
  family-names: "Dotson"
  orcid: "https://orcid.org/0000-0001-5879-2942"
- given-names: Joshua T.
  family-names: Horton
  orcid: 'https://orcid.org/0000-0001-8694-7200'
- given-names: Matthew
  family-names: Thompson
  orcid: 'https://orcid.org/0000-0002-1460-3983'
- given-names: Alyssa
  family-names: Travitz
  orcid: 'https://orcid.org/0000-0001-5953-8807'
title: "The Open Free Energy library"
version: 1.7.0
date-released: 2025-04-25
url: "https://openfree.energy/"
repository-code: "https://github.com/openfreeEnergy/openfe"
doi: 10.5281/zenodo.8344247

Committers

Last synced: almost 3 years ago

All Time
  • Total Commits: 774
  • Total Committers: 10
  • Avg Commits per committer: 77.4
  • Development Distribution Score (DDS): 0.798
Past Year
  • Commits: 610
  • Committers: 9
  • Avg Commits per committer: 67.778
  • Development Distribution Score (DDS): 0.744
Top Committers
Name Email Commits
riesben b****s@o****m 156
richard r****s@g****m 152
David W.H. Swenson d****n@o****o 124
richard r****d@n****m 113
IAlibay i****y@m****g 102
Mike Henry 1****y@u****m 59
Irfan Alibay I****y@u****m 49
Irfan i****y@g****m 11
David Dotson d****l@g****m 7
Richard Gowers r****b@g****m 1
Committer Domains (Top 20 + Academic)

Issues and Pull Requests

Last synced: 6 months ago

All Time
  • Total issues: 473
  • Total pull requests: 518
  • Average time to close issues: 3 months
  • Average time to close pull requests: 12 days
  • Total issue authors: 54
  • Total pull request authors: 21
  • Average comments per issue: 0.92
  • Average comments per pull request: 2.8
  • Merged pull requests: 351
  • Bot issues: 0
  • Bot pull requests: 1
Past Year
  • Issues: 257
  • Pull requests: 260
  • Average time to close issues: 24 days
  • Average time to close pull requests: 5 days
  • Issue authors: 30
  • Pull request authors: 12
  • Average comments per issue: 0.74
  • Average comments per pull request: 2.97
  • Merged pull requests: 159
  • Bot issues: 0
  • Bot pull requests: 1
Top Authors
Issue Authors
  • IAlibay (207)
  • atravitz (79)
  • richardjgowers (32)
  • mikemhenry (32)
  • jameseastwood (19)
  • jthorton (15)
  • hannahbaumann (15)
  • dwhswenson (6)
  • chabi-fin (6)
  • dotsdl (4)
  • RiesBen (4)
  • mattwthompson (3)
  • Kamecs (3)
  • wenchangzhou-qtx (2)
  • nffaruk (2)
Pull Request Authors
  • atravitz (144)
  • IAlibay (118)
  • mikemhenry (91)
  • richardjgowers (53)
  • dwhswenson (38)
  • hannahbaumann (18)
  • jthorton (17)
  • RiesBen (11)
  • mattwthompson (10)
  • dotsdl (4)
  • ijpulidos (2)
  • frannerin (2)
  • Yoshanuikabundi (2)
  • slochower (1)
  • CurtisColwell (1)
Top Labels
Issue Labels
cli (27) 1.0docdrive (24) documentation (23) openfe (13) bug (9) priority:low (9) priority:high (8) cookbook (5) openmm_rbfe (5) testing (5) enhancement (4) deployment (3) priority:medium (3) userguide (2) in-progress (1) question (1)
Pull Request Labels
1.0docdrive (13) priority:medium (4) enhancement (3) testing (3) cli (3) bug (3) priority:high (2) deployment (1) priority:low (1) networkplanning (1) documentation (1) duplicate (1)

Packages

  • Total packages: 1
  • Total downloads: unknown
  • Total dependent packages: 0
  • Total dependent repositories: 1
  • Total versions: 5
conda-forge.org: openfe

The Open Free Energy (OpenFE) project is dedicated to the maintenance and development of open source tools for free energy calculations to guide pharmaceutical drug design and discovery. This package enables researchers to plan, execute, and analyze networks of free energy calculations.

  • Versions: 5
  • Dependent Packages: 0
  • Dependent Repositories: 1
Rankings
Dependent repos count: 24.1%
Stargazers count: 37.6%
Average: 39.8%
Forks count: 46.0%
Dependent packages count: 51.5%
Last synced: 6 months ago