dna_replication_model - A Model of DNA Replication Timing

Toolkit for analysing DNA replication timing, origin firing rates, and genomic stability across human cell lines and chromosomal regions. Includes functions for processing and visualising data across whole-genome regions, telomeres, centromeres, and user-defined loci. By fitting origin firing rates to replication timing profiles, the model enables prediction and comparison with experimental data. Error analysis highlights regions of interest and potential instability. This release accompanies Berkemeier et al. (2025) and supports exploration of replication dynamics across diverse genomic contexts.

- Jupyter Notebook
Published by fberkemeier 10 months ago