Data

Tools

Indexes

Applications

Experiments

Open Source Science

drosophila_neurotransmitters

Neurotransmitter ground truth

https://github.com/funkelab/drosophila_neurotransmitters

Science Score: 44.0%

This score indicates how likely this project is to be science-related based on various indicators:

  • ✓
    CITATION.cff file
    Found CITATION.cff file
  • ✓
    codemeta.json file
    Found codemeta.json file
  • ✓
    .zenodo.json file
    Found .zenodo.json file
  • ○
    DOI references
  • ○
    Academic publication links
  • ○
    Academic email domains
  • ○
    Institutional organization owner
  • ○
    JOSS paper metadata
  • ○
    Scientific vocabulary similarity
    Low similarity (12.6%) to scientific vocabulary
Last synced: 6 months ago · JSON representation ·

Repository

Neurotransmitter ground truth

Basic Info
  • Host: GitHub
  • Owner: funkelab
  • Language: TeX
  • Default Branch: main
  • Size: 11.7 MB
Statistics
  • Stars: 1
  • Watchers: 7
  • Forks: 1
  • Open Issues: 4
  • Releases: 0
Created almost 2 years ago · Last pushed 6 months ago
Metadata Files
Readme Contributing Citation

README.md

Drosophila Neurotransmitters

This repository contains curated data on neurotransmitters used by different cell types (Bates et al. 2019) in Drosophila melanogaster. The data is stored in a version-controlled .csv file named gt_data.csv, with changes managed through GitHub Pull Requests.

For a complete list of references for our ground truth, please see our CITATIONS.md file.

fafb_783_known_nts

Scope

This repository focuses on fast-acting small molecule transmitters, including:

  • Acetylcholine: The primary excitatory neurotransmitter in the insect central nervous system, crucial for learning and memory.
  • Glutamate: Can be either excitatory of inhibitory in the central nervous system, depending on the downstream receptor.
  • GABA (γ-Aminobutyric acid): The main inhibitory neurotransmitter in the adult fly brain.
  • Glycine: While less common in Drosophila, it can act as an inhibitory neurotransmitter in some neurons.
  • Dopamine: Involved in reward, motivation, and motor control; important for learning and memory.
  • Serotonin: Regulates various behaviors including sleep, feeding, and aggression.
  • Octopamine: Often described as the insect analogue of norepinephrine, involved in arousal and aggression.
  • Tyramine: Precursor to octopamine, also functions as a neurotransmitter affecting various behaviors.
  • Histamine: Primary neurotransmitter in photoreceptors and some mechanosensory neurons.
  • Nitric oxide: A gaseous signaling molecule involved in various physiological processes including memory formation.

For neuropeptide annotation, please refer to our separate repository: funkelab/drosophila_neuropeptides.

How to Contribute Data

For Git Novices

  1. Download the gt_data.csv file and open it with your preferred spreadsheet application.
  2. Add your data to the bottom of the file and save it as a CSV.
  3. On the repository page, click the "+" sign next to "Code" and select "Upload Files".
  4. Upload your modified gt_data.csv file, ensuring the filename remains unchanged.
  5. Fill in the commit form:
    • Provide a concise description of your changes in the first field.
    • Add more detailed information in the "Add an optional extended description..." field.
  6. Select "Create a new branch for this commit and start a pull request".
  7. Review your changes on the "Open a pull request" page and click "Create pull request".
  8. Wait for review from a maintainer. Be prepared to answer follow-up questions about your data.

For Git Users

  1. Clone this repository and create a new branch.
  2. Modify the gt_data.csv file.
  3. Commit your changes with a meaningful commit message and push to your branch.
  4. Create a Pull Request for your branch when you're satisfied with your changes.

Our Goal

Our goal is to collate as much data from the literature as possible, linking neurotransmitter information to neuronal cell types from connectomic datasets. Current datasets include:

  • FAFB-FlyWire (whole brain)
  • HemiBrain (partial midbrain)
  • FANC (ventral nerve cord)
  • MANC (ventral nerve cord)
  • optic-lobe (optic lobe)
  • maleCNS (whole nervous system)
  • BANC (whole nervous system)
  • L1 (whole larval nervous system)

The gt_data.csv file contains one row per cell type and study, where a given study has identified one or more small molecule transmitters used by a specific cell type.

Cross data set cell type mapping is given in the file: /inst/extdata/cell_type_cross_matching.csv

We have predicted a smaller set of transmitter in MANC, FAFB-FlyWire and Hemibrain (Eckstein and Bates et al., 2024).

About the data

We aim to collate as much data from the literature as possible, that can be linked to a neuronal cell type from a connectoem dataset. At present, those datasets are FAFB-FlyWire (whole brain), HemiBrain (partial midbrain), FANC (ventral nerve cord), MANC (ventral nerve cord), optic-lobe (optic lobe), maleCNS (whole nervous system), BANC (whole nervous system) and the L1 (whole larval nervous system).

The file gt_data.csv contains one row per cell type + study, where the given study has identified a small molecule transmitter (or multiple transmitters) used by the given cell type.

It uses a single cell type name, that can be linked between connectomes using the file exdata/cell_type_cross_matching.csv.

The data columns are:

species - the species name for the observation, for now this is only d. melanogaster

region - the gross subregion for the cell type, i.e. midbrain, optic lobes, ventral nerve cord

hemilineage - the hemilineage bundle to which the cell type belongs, in the nomenclature of Ito et al., 2013 and (midbrain), or (ventral nerve cord)

cell_type - a cell type name relevant to one of the connectomic datasets. In general, we prefer a FAFB-FlyWire (brain) or MANC (ventral nerve cord) name.

neurotransmitterverifiedsource - the name of the study from which the observation this row records has originated. Note, rows are unique combinations of cell_type and neurotransmitter_verified_source, so each can repeat over multiple rows if many studies look at the same cell type, or information on many cell types has been reported by the same study.

neurotransmitterverifiedevidence - the method used by the given study to determine transmission.

neurotransmitterverifiedconfidence - an expression of how confident you are that the study has correctly identified the right transmitter for the given cell type, and how well that cell type has been matched to connectome data. Scores ~indicate: - 5: evidence for protein expression in the given cell type, cell type specific labelling. - 4: evidence for protein expression with coarser anatomical detail / reliable transcript expression using in-situ hybridisation, and ideally for which some negative data is available (different transmitter options tried per cell type) - 3: identification of RNA transcripts related to transmitter expression, - 2: Unreliable morphological match to the EM / more bulk RNA sequencing / gross neuroanatomy based on immunohistochemistry - 1: Genetic knockdown, e.g. RNAi of transmitter pathways / speculative morphological matches to EM - 0: Educated guesses at transmission based on any of the above, but lacking anatomical precision in matching to the EM.

acetylcholine, glutamate, gaba, glycine,dopamine,serotonin, octopamine, tyramine, histamine, nitric oxide - Each small molecule transmitter column contains a -1, 0 or 1. 1 = positive evidence for transmitter usage, 0 = no evidence either way for transmitter usage, -1 = negative evidence for transmitter usage. Due to the way wetlab reports are gathered and conveyed, there is relatively little negative data from the literature but it is useful - and so we really encourage you to add it, if you have it!

This project started in June 2024 with >900 cell types identified across 71 studies in adult D. melanogaster, perhaps ~30% of the central nervous system. The folder gt_sources contain some tables from a few of these studies, which we used to help build this data. We encourage you to submit such tables to this folder as well.

Data overview

As of 20th July 2024, the data we have include, in the FAFB-783 dataset:

```

Synapses

acetylcholine 27888474 dopamine 695904 gaba 7872711 glutamate 7095890 serotonin 320187 tyramine 283593 histamine 1103457 glycine 6430 nitric_oxide 2461618 octopamine 295673

Neurons

acetylcholine 51559 dopamine 1411 gaba 8962 glutamate 11408 serotonin 102 tyramine 104 histamine 12120 glycine 7 nitric_oxide 4499 octopamine 62

Cell types

acetylcholine 442 dopamine 58 gaba 199 glutamate 166 serotonin 30 tyramine 16 histamine 5 glycine 1 nitric_oxide 10 octopamine 21 ```

Here we can see the synapse counts (note log scale) by confidence bin for out different ground-truth classes. The bars are in order of increasing confidence threshold (so left-most blue is Ach with confidence >= 1 and right-most blue is Ach with confidence >=5):

synapses_known_nt

The same, for neuron counts:

neurons_known_nt

The same, for cell type counts:

cell_types_known_nt

Acknowledgements

As of July 20th 2024 -- repo private

This data was collated by Alexander Bates at Harvard Medical School while in the group of Prof. Rachel Wilson It is manageed and curated together with Diane Adjavon in the laboratory of Jan Funke at Janelia Research Campus. We thank Mark Eddison at Janelia for sharing early assignment of EASI-FISH data for central complex neurons.

If you use this collected data in your research please liaise with Alex, Diane and Jan on the appropriate ways to acknowledge this resource.

Citations

  1. Bates, A. S., Janssens, J., Jefferis, G. S., & Aerts, S. (2019). Neuronal cell types in the fly: single-cell anatomy meets single-cell genomics. Current Opinion in Neurobiology, 56, 125-134.

  2. Eckstein, N., Bates, A. S., Champion, A., Du, M., Yin, Y., Schlegel, P., ... & Funke, J. (2024). Neurotransmitter classification from electron microscopy images at synaptic sites in Drosophila melanogaster. Cell, 187(10), 2574-2594.

For a complete list of references, please see our CITATIONS.md file.

Contact

For questions or concerns, please open an issue in this repository or contact alexander_bates[at]hms.harvard.edu.

Owner

  • Name: Funke lab
  • Login: funkelab
  • Kind: organization
  • Email: funkej@janelia.hhmi.org

Janelia Research Campus

Citation (CITATIONS.md) 

# Citations for neuronal transmission ground-truth
## updated 2024-12-05

1.	Alekseyenko, O. V., Lee, C. & Kravitz, E. A. Targeted manipulation of serotonergic neurotransmission affects the escalation of aggression in adult male Drosophila melanogaster. PLoS One 5, e10806 (2010).

2.	Alekseyenko, O. V., Chan, Y.-B., Li, R. & Kravitz, E. A. Single dopaminergic neurons that modulate aggression in Drosophila. Proc. Natl. Acad. Sci. U. S. A. 110, 6151–6156 (2013).

3.	Brown, M. P. et al. A subclass of evening cells promotes the switch from arousal to sleep at dusk. Curr. Biol. 34, 2186–2199.e3 (2024).

4.	Aso, Y. et al. The neuronal architecture of the mushroom body provides a logic for associative learning. Elife 1–47 (2014).

5.	Barnstedt, O. et al. Memory-Relevant Mushroom Body Output Synapses Are Cholinergic. Neuron 89, 1237–1247 (2016).

6.	Busch, S., Selcho, M., Ito, K. & Tanimoto, H. A map of octopaminergic neurons in the Drosophila brain. J. Comp. Neurol. 513, 643–667 (2009).

7.	Aso, Y. et al. Nitric oxide acts as a cotransmitter in a subset of dopaminergic neurons to diversify memory dynamics. Elife 8, (2019).

8.	Cao, C. & Brown, M. R. Localization of an insulin-like peptide in brains of two flies. Cell Tissue Res. 304, 317–321 (2001).

9.	Carlsson, M. A., Diesner, M., Schachtner, J. & Nässel, D. R. Multiple neuropeptides in the Drosophila antennal lobe suggest complex modulatory circuits. J. Comp. Neurol. 518, 3359–3380 (2010).

10.	Cavanaugh, D. J., Vigderman, A. S., Dean, T., Garbe, D. S. & Sehgal, A. The Drosophila circadian clock gates sleep through time-of-day dependent modulation of sleep-promoting neurons. Sleep 39, 345–356 (2016).

11.	Certel, S. J. et al. Octopamine neuromodulatory effects on a social behavior decision-making network in Drosophila males. PLoS One 5, e13248 (2010).

12.	Chen, J. et al. Isoform-specific expression of the neuropeptide orcokinin in Drosophila melanogaster. Peptides 68, 50–57 (2015).

13.	Cheong, H. S. J. et al. Transforming descending input into behavior: The organization of premotor circuits in the Drosophila Male Adult Nerve Cord connectome. (2024) doi:10.7554/elife.96084.1.

14.	Chiang, A.-S. et al. Three-dimensional reconstruction of brain-wide wiring networks in Drosophila at single-cell resolution. Curr. Biol. 21, 1–11 (2011).

15.	Chou, Y.-H. et al. Mating-driven variability in olfactory local interneuron wiring. Sci. Adv. 8, eabm7723 (2022).

16.	Croset, V., Treiber, C. & Waddell, S. Cellular diversity in the Drosophila midbrain revealed by single-cell transcriptomics. Elife 7, e34550 (2018).

17.	Dacks, A. M., Christensen, T. A. & Hildebrand, J. G. Phylogeny of a serotonin-immunoreactive neuron in the primary olfactory center of the insect brain. J. Comp. Neurol. 498, 727–746 (2006).

18.	Davis, F. P. et al. A genetic, genomic, and computational resource for exploring neural circuit function. Elife 9, (2020).

19.	Deng, B. et al. Chemoconnectomics: Mapping Chemical Transmission in Drosophila. Neuron 101, 876–893.e4 (2019).

20.	Schlichting, M., Díaz, M. M., Xin, J. & Rosbash, M. Neuron-specific knockouts indicate the importance of network communication to Drosophila rhythmicity. Elife 8, (2019).

21.	Dolan, M.-J. et al. Facilitating Neuron-Specific Genetic Manipulations in Drosophila melanogaster Using a Split GAL4 Repressor. Genetics 206, 775–784 (2017).

22.	Dolan, M.-J. et al. Neurogenetic dissection of the Drosophila lateral horn reveals major outputs, diverse behavioural functions, and interactions with the mushroom body. Elife 8, e43079 (2019).

23.	Syed, S., Duan, Y. & Lim, B. Modulation of protein-DNA binding reveals mechanisms of spatiotemporal gene control in early Drosophila embryos. Elife 12, (2023).

24.	Frenkel, L. et al. Organization of Circadian Behavior Relies on Glycinergic Transmission. Cell Rep. 19, 72–85 (2017).

25.	Gao, S. et al. The neural substrate of spectral preference in Drosophila. Neuron 60, 328–342 (2008).

26.	Goda, T. et al. Drosophila DH31 neuropeptide and PDF receptor regulate night-onset temperature preference. J. Neurosci. 36, 11739–11754 (2016).

27.	González Segarra, A. J., Pontes, G., Jourjine, N., Del Toro, A. & Scott, K. Hunger- and thirst-sensing neurons modulate a neuroendocrine network to coordinate sugar and water ingestion. Elife 12, (2023).

28.	Guo, Y., Flegel, K., Kumar, J., McKay, D. J. & Buttitta, L. A. Ecdysone signaling induces two phases of cell cycle exit in Drosophila cells. Biol. Open 5, 1648–1661 (2016).

29.	Hasenhuetl, P. S. et al. A half-centre oscillator encodes sleep pressure. bioRxiv (2024) doi:10.1101/2024.02.23.581780.

30.	Haynes, P. R., Christmann, B. L. & Griffith, L. C. A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster. Elife 4, e03868 (2015).

31.	Hergarden, A. C., Tayler, T. D. & Anderson, D. J. Allatostatin-A neurons inhibit feeding behavior in adult Drosophila. Proc. Natl. Acad. Sci. U. S. A. 109, 3967–3972 (2012).

32.	Hermann-Luibl, C., Yoshii, T., Senthilan, P. R., Dircksen, H. & Helfrich-Förster, C. The ion transport peptide is a new functional clock neuropeptide in the fruit fly Drosophila melanogaster. J. Neurosci. 34, 9522–9536 (2014).

33.	Hulse, B. K. et al. A connectome of the Drosophila central complex reveals network motifs suitable for flexible navigation and context-dependent action selection. Elife 10, e66039 (2021).

34.	Isaacson, M. D. et al. Small-field visual projection neurons detect translational optic flow and support walking control. bioRxiv (2023) doi:10.1101/2023.06.21.546024.

35.	Ito, M., Masuda, N., Shinomiya, K., Endo, K. & Ito, K. Systematic Analysis of Neural Projections Reveals Clonal Composition of the Drosophila Brain. Curr. Biol. 23, 644–655 (2013).

36.	Jiang, H. et al. Natalisin, a tachykinin-like signaling system, regulates sexual activity and fecundity in insects. Proc. Natl. Acad. Sci. U. S. A. 110, E3526–34 (2013).

37.	Jin, X. et al. A subset of DN1p neurons integrates thermosensory inputs to promote wakefulness via CNMa signaling. Curr. Biol. 31, 2075–2087.e6 (2021).

38.	Johard, H. A. D. et al. Intrinsic neurons of Drosophila mushroom bodies express short neuropeptide F: relations to extrinsic neurons expressing different neurotransmitters. J. Comp. Neurol. 507, 1479–1496 (2008).

39.	Jones, J. D. et al. The dorsal fan-shaped body is a neurochemically heterogeneous sleep-regulating center in Drosophila. bioRxiv (2024) doi:10.1101/2024.04.10.588925.

40.	Konstantinides, N. et al. Phenotypic convergence: Distinct transcription factors regulate common terminal features. Cell 174, 622–635.e13 (2018).

41.	Konstantinides, N. et al. A complete temporal transcription factor series in the fly visual system. Nature 604, 316–322 (2022).

42.	Krashes, M. J. et al. A neural circuit mechanism integrating motivational state with memory expression in Drosophila. Cell 139, 416–427 (2009).

43.	Krzeptowski, W. et al. Mesencephalic Astrocyte-derived Neurotrophic Factor regulates morphology of pigment-dispersing factor-positive clock neurons and circadian neuronal plasticity in Drosophila melanogaster. Front. Physiol. 12, 705183 (2021).

44.	Kubrak, O. I., Lushchak, O. V., Zandawala, M. & Nässel, D. R. Systemic corazonin signalling modulates stress responses and metabolism in Drosophila. Open Biol. 6, (2016).

45.	Landayan, D., Wang, B. P., Zhou, J. & Wolf, F. W. Thirst interneurons that promote water seeking and limit feeding behavior in Drosophila. Elife 10, (2021).

46.	Lee, Y.-J. et al. Conservation and divergence of related neuronal lineages in the Drosophila central brain. Elife 9, (2020).

47.	Liang, L. et al. GABAergic Projection Neurons Route Selective Olfactory Inputs to Specific Higher-Order Neurons. Neuron 79, 917–931 (2013).

48.	Liu, X. & Davis, R. L. The GABAergic anterior paired lateral neuron suppresses and is suppressed by olfactory learning. Nat. Neurosci. 12, 53–59 (2009).

49.	Lu, J. et al. Transforming representations of movement from body- to world-centric space. Nature 601, 98–104 (2022).

50.	Ma, D. et al. A transcriptomic taxonomy of Drosophila circadian neurons around the clock. Elife 10, (2021).

51.	Mao, Z. & Davis, R. L. Eight different types of dopaminergic neurons innervate the Drosophila mushroom body neuropil: anatomical and physiological heterogeneity. Front. Neural Circuits 3, 5 (2009).

52.	Mao, R. et al. Conditional chemoconnectomics (cCCTomics) as a strategy for efficient and conditional targeting of chemical transmission. Elife 12, (2024).

53.	Martelli, C. et al. SIFamide Translates Hunger Signals into Appetitive and Feeding Behavior in Drosophila. (2017) doi:10.1016/j.celrep.2017.06.043.

54.	Matheson, A. M. M. et al. Addendum: A neural circuit for wind-guided olfactory navigation. Nat. Commun. 15, 1903 (2024).

55.	Mattaliano, M. D., Montana, E. S., Parisky, K. M., Littleton, J. T. & Griffith, L. C. The Drosophila ARC homolog regulates behavioral responses to starvation. Mol. Cell. Neurosci. 36, 211–221 (2007).

56.	Mauss, A. S., Meier, M., Serbe, E. & Borst, A. Optogenetic and pharmacologic dissection of feedforward inhibition in Drosophila motion vision. J. Neurosci. 34, 2254–2263 (2014).

57.	McKim, T. H. et al. Synaptic connectome of a neurosecretory network in the Drosophila brain. bioRxivorg (2024) doi:10.1101/2024.08.28.609616.

58.	Meiselman, M. R. et al. Recovery from cold-induced reproductive dormancy is regulated by temperature-dependent AstC signaling. Curr. Biol. 32, 1362–1375.e8 (2022).

59.	Meschi, E., Duquenoy, L., Otto, N., Dempsey, G. & Waddell, S. Compensatory enhancement of input maintains aversive dopaminergic reinforcement in hungry Drosophila. Neuron 112, 2315–2332.e8 (2024).

60.	Mollá-Albaladejo, R., Jiménez-Caballero, M. & Sánchez-Alcañiz, J. A. Molecular characterization of gustatory second-order neurons reveals integrative mechanisms of gustatory and metabolic information. (2024) doi:10.7554/elife.100947.1.

61.	Nässel, D. R. & Elekes, K. Aminergic neurons in the brain of blowflies and Drosophila: dopamine- and tyrosine hydroxylase-immunoreactive neurons and their relationship with putative histaminergic neurons. Cell Tissue Res. 267, 147–167 (1992).

62.	Nässel, D. R., Enell, L. E., Santos, J. G., Wegener, C. & Johard, H. A. D. A large population of diverse neurons in the Drosophila central nervous system expresses short neuropeptide F, suggesting multiple distributed peptide functions. BMC Neurosci. 9, 90 (2008).

63.	Nern, A. et al. Connectome-driven neural inventory of a complete visual system. bioRxiv (2024) doi:10.1101/2024.04.16.589741.

64.	Ni, J. D. et al. Differential regulation of the Drosophila sleep homeostat by circadian and arousal inputs. Elife 8, (2019).

65.	Niens, J. et al. Dopamine Modulates Serotonin Innervation in the Drosophila Brain. Front. Syst. Neurosci. 11, 76 (2017).

66.	Palavicino-Maggio, C. B., Chan, Y.-B., McKellar, C. & Kravitz, E. A. A small number of cholinergic neurons mediate hyperaggression in female Drosophila. Proceedings of the National Academy of Sciences 116, 17029–17038 (2019).

67.	Pooryasin, A. & Fiala, A. Identified serotonin-releasing neurons induce behavioral quiescence and suppress mating in Drosophila. J. Neurosci. 35, 12792–12812 (2015).

68.	Reinhard, N. et al. Synaptic connectome of theDrosophilacircadian clock. (2023) doi:10.1101/2023.09.11.557222.

69.	Scheunemann, L., Plaçais, P.-Y., Dromard, Y., Schwärzel, M. & Preat, T. Dunce Phosphodiesterase Acts as a Checkpoint for Drosophila Long-Term Memory in a Pair of Serotonergic Neurons. Neuron 98, 350–365.e5 (2018).

70.	Scott, R. L. et al. Non-canonical eclosion hormone-expressing cells regulate Drosophila ecdysis. iScience 23, 101108 (2020).

71.	Shang, Y., Claridge-Chang, A., Sjulson, L., Pypaert, M. & Miesenböck, G. Excitatory local circuits and their implications for olfactory processing in the fly antennal lobe. Cell 128, 601–612 (2007).

72.	Shinomiya, K. et al. Candidate neural substrates for off-edge motion detection in Drosophila. Curr. Biol. 24, 1062–1070 (2014).

73.	Sinakevitch, I. & Strausfeld, N. J. Comparison of octopamine-like immunoreactivity in the brains of the fruit fly and blow fly. J. Comp. Neurol. 494, 460–475 (2006).

74.	Sitaraman, D. et al. Serotonin is necessary for place memory in Drosophila. Proc. Natl. Acad. Sci. U. S. A. 105, 5579–5584 (2008).

75.	Sizemore, T. R., Jonaitis, J. & Dacks, A. M. Heterogeneous receptor expression underlies non-uniform peptidergic modulation of olfaction in Drosophila. Nat. Commun. 14, 5280 (2023).

76.	Söderberg, J. A. E., Carlsson, M. A. & Nässel, D. R. Insulin-producing cells in the Drosophila brain also express satiety-inducing cholecystokinin-like peptide, drosulfakinin. Front. Endocrinol. (Lausanne) 3, 109 (2012).

77.	Song, T. et al. Dietary cysteine drives body fat loss via FMRFamide signaling in Drosophila and mouse. Cell Res. 33, 434–447 (2023).

78.	Sun, L., Jiang, R. H., Ye, W. J., Rosbash, M. & Guo, F. Recurrent circadian circuitry regulates central brain activity to maintain sleep. Neuron 110, 2139–2154.e5 (2022).

79.	Takemura, S.-Y. et al. Cholinergic circuits integrate neighboring visual signals in a Drosophila motion detection pathway. Curr. Biol. 21, 2077–2084 (2011).

80.	Shinomiya, K. et al. A common evolutionary origin for the ON- and OFF-edge motion detection pathways of the Drosophila visual system. Front. Neural Circuits 9, 33 (2015).

81.	Tanaka, N. K., Endo, K. & Ito, K. Organization of antennal lobe-associated neurons in adult Drosophila melanogaster brain. J. Comp. Neurol. 520, 4067–4130 (2012).

82.	Turner-Evans, D. B. et al. The Neuroanatomical Ultrastructure and Function of a Biological Ring Attractor. Neuron 108, 145–163.e10 (2020).

83.	Raghu, S. V. & Borst, A. Candidate glutamatergic neurons in the visual system of Drosophila. PLoS One 6, e19472 (2011).

84.	Vitzthum, H., Homberg, U. & Agricola, H. Distribution of Dip-allatostatin I-like immunoreactivity in the brain of the locust Schistocerca gregaria with detailed analysis of immunostaining in the central complex. J. Comp. Neurol. 369, 419–437 (1996).

85.	Waddell, S., Douglas Armstrong, J., Kitamoto, T., Kaiser, K. & Quinn, W. G. The amnesiac Gene Product Is Expressed in Two Neurons in the Drosophila Brain that Are Critical for Memory. Cell 103, 805–813 (2000).

86.	Wang, F. et al. Neural circuitry linking mating and egg laying in Drosophila females. Nature 579, 101–105 (2020).

87.	Wang, K. et al. Neural circuit mechanisms of sexual receptivity in Drosophila females. Nature 589, 577–581 (2021).

88.	Wei, H., Kyung, H. Y., Kim, P. J. & Desplan, C. The diversity of lobula plate tangential cells (LPTCs) in the Drosophila motion vision system. J. Comp. Physiol. A Neuroethol. Sens. Neural Behav. Physiol. 206, 139–148 (2020).

89.	Winther, A. M. E., Siviter, R. J., Isaac, R. E., Predel, R. & Nässel, D. R. Neuronal expression of tachykinin-related peptides and gene transcript during postembryonic development of Drosophila: TRP and Gene Transcript Expression inDrosophila. J. Comp. Neurol. 464, 180–196 (2003).

90.	Wolff, T. et al. Cell type-specific driver lines targeting the Drosophila central complex and their use to investigate neuropeptide expression and sleep regulation. bioRxivorg (2024) doi:10.1101/2024.10.21.619448.

91.	Wu, Y., Bidaye, S. S. & Mahringer, D. Drosophilafemale-specific brain neuron elicits persistent position- and direction-selective male-like social behaviors. (2019) doi:10.1101/594960.

92.	Xie, X. et al. The laminar organization of the Drosophila ellipsoid body is semaphorin-dependent and prevents the formation of ectopic synaptic connections. Elife 6, (2017).

93.	Yao, Z. & Scott, K. Serotonergic neurons translate taste detection into internal nutrient regulation. Neuron 110, 1036–1050.e7 (2022).

94.	Yurgel, M. E. et al. A single pair of leucokinin neurons are modulated by feeding state and regulate sleep-metabolism interactions. PLoS Biol. 17, e2006409 (2019).

95.	Zhao, A. et al. A comprehensive neuroanatomical survey of the Drosophila Lobula Plate Tangential Neurons with predictions for their optic flow sensitivity. bioRxivorg (2023) doi:10.1101/2023.10.16.562634.

GitHub Events

Total
  • Issues event: 9
  • Watch event: 1
  • Issue comment event: 19
  • Push event: 9
  • Public event: 1
Last Year
  • Issues event: 9
  • Watch event: 1
  • Issue comment event: 19
  • Push event: 9
  • Public event: 1