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dapagliflozin-model

https://github.com/matthiaskoenig/dapagliflozin-model

Science Score: 49.0%

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    CITATION.cff file
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    Found codemeta.json file
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    Found .zenodo.json file
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    DOI references
    Found 10 DOI reference(s) in README
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    Links to: zenodo.org
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    Low similarity (3.1%) to scientific vocabulary
Last synced: 6 months ago · JSON representation

Repository

Basic Info
  • Host: GitHub
  • Owner: matthiaskoenig
  • Language: HTML
  • Default Branch: main
  • Size: 63 MB
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  • Stars: 0
  • Watchers: 1
  • Forks: 0
  • Open Issues: 0
  • Releases: 6
Created over 1 year ago · Last pushed 9 months ago
Metadata Files
Readme Zenodo

README.md

DOI

dapagliflozin model

This repository provides the dapagliflozin physiologically based pharmacokinetics (PBPK) model.

The model is distributed as SBML available from dapagliflozin_body_flat.xml with corresponding SBML4humans model report at https://sbml4humans.de/modelurl?url=https://raw.githubusercontent.com/matthiaskoenig/dapagliflozin-model/main/models/dapagliflozinbody_flat.xml and equations from dapagliflozin_body_flat.md.

model overview

Comp submodels

The liver submodel is available from dapagliflozin_liver.xml with corresponding SBML4humans report at https://sbml4humans.de/modelurl?url=https://raw.githubusercontent.com/matthiaskoenig/dapagliflozin-model/main/models/dapagliflozinliver.xml and equations from dapagliflozin_liver.md.

The kidney submodel is available from dapagliflozin_kidney.xml with corresponding SBML4humans report at https://sbml4humans.de/modelurl?url=https://raw.githubusercontent.com/matthiaskoenig/dapagliflozin-model/main/models/dapagliflozinkidney.xml and equations from dapagliflozin_kidney.md.

The intestine submodel is available from dapagliflozin_intestine.xml with corresponding SBML4humans report at https://sbml4humans.de/modelurl?url=https://raw.githubusercontent.com/matthiaskoenig/dapagliflozin-model/main/models/dapagliflozinintestine.xml and equations from dapagliflozin_intestine.md.

The whole-body submodel is available from dapagliflozin_body.xml with corresponding SBML4humans report at https://sbml4humans.de/modelurl?url=https://raw.githubusercontent.com/matthiaskoenig/dapagliflozin-model/main/models/dapagliflozinbody.xml and equations from dapagliflozin_body.md.

How to cite

DOI

Nemitz, N., & Knig, M. (2025). Physiologically based pharmacokinetic (PBPK) model of dapagliflozin.
Zenodo. https://doi.org/10.5281/zenodo.13987865

License

This program is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.

Funding

Matthias Knig was supported by the Federal Ministry of Education and Research (BMBF, Germany) within LiSyM by grant number 031L0054 and ATLAS by grant number 031L0304B and by the German Research Foundation (DFG) within the Research Unit Program FOR 5151 QuaLiPerF (Quantifying Liver Perfusion-Function Relationship in Complex Resection - A Systems Medicine Approach) by grant number 436883643 and by grant number 465194077 (Priority Programme SPP 2311, Subproject SimLivA). This work was supported by the BMBF-funded de.NBI Cloud within the German Network for Bioinformatics Infrastructure (de.NBI) (031A537B, 031A533A, 031A538A, 031A533B, 031A535A, 031A537C, 031A534A, 031A532B).

2024-2025 Nike Nemitz & Matthias Knig, Systems Medicine of the Liver

Owner

  • Name: Matthias König
  • Login: matthiaskoenig
  • Kind: user
  • Location: Berlin
  • Company: Humboldt University

Matthias König (PhD. in Biophysics) leads a junior research group for Systems Biology and Systems Medicine of the liver.

GitHub Events

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