dataset

https://github.com/quannguyeniu/dataset
Science Score: 18.0%

This score indicates how likely this project is to be science-related based on various indicators:
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CITATION.cff file
Found CITATION.cff file
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codemeta.json file
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.zenodo.json file
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DOI references
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Academic links in README
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Academic email domains
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Institutional organization owner
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JOSS paper metadata
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Scientific vocabulary similarity
Low similarity (0.2%) to scientific vocabulary
Last synced: 10 months ago · JSON representation ·
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Created about 5 years ago · Last pushed over 3 years ago
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Profile: https://github.com/QuanNguyenIU
Citation (citation_1_sample_50k.csv)

doi,articleType,citationStyle,citationStringAnnotated
10.1042/bj0980742,3,623,"<author><family>Glimcher</family> <given>M</given>, <family>Levine</family> <given>P</given></author>. <title>Studies of the proteins, peptides and free amino acids of mature bovine enamel</title>. <container-title>Biochem J</container-title> [Internet] <issued><year>1966</year></issued>;<volume>98</volume>:<page>742–753</page>. <publisher>Portland Press Ltd.</publisher>."
10.1002/pdi.v4:1,37,1331,. <container-title>Pract Diab Int</container-title> <issued><year>1987</year></issued>; <volume>4</volume>Available from: <URL>http://dx.doi.org/10.1002/pdi.v4:1</URL>
10.1007/bf01761302,3,1107,<author><family>Witebsky</family> <given>E</given></author>. <title>Ein Neues Gonokokkenantigen</title>. <container-title>Klinische Wochenschrift</container-title> <issued><year>1933</year></issued>;<volume>12</volume>:<page>1455–1456</page>.
10.1053/j.seminhematol.2016.11.003,3,746,"<author><family>Brown</family>, <given>A. L.</given>; <family>Churpek</family>, <given>J. E.</given>; <family>Malcovati</family>, <given>L.</given>; <family>Döhner</family>, <given>H.</given>; <family>Godley</family>, <given>L. A.</given></author>, <issued><year>2017</year></issued>: <title>Recognition of familial myeloid neoplasia in adults</title>. <container-title>Seminars in Hematology</container-title>., <volume>54</volume>, <page>60–68</page>."
10.1121/1.4987594,3,1338,"<author><family>Goodman</family>, <given>D. F.</given></author> [<issued><year>2017</year></issued>]: <title>“On the Use of Hypothesis-Driven Reduced Models in Auditory Neuroscience”</title>, <container-title>The Journal of the Acoustical Society of America</container-title>, <volume>141</volume>, pp. <page>3573–3573</page>, &lt;<URL>http://dx.doi.org/10.1121/1.4987594.</URL>&gt;"
10.1021/acsnano.7b02607,3,47,"<author><family>Brownlee</family>, <given>C.</given></author> (<issued><year>2017</year></issued>), <title>“In Nano, Volume 11, Issue 4,”</title> <container-title>ACS Nano</container-title>, <publisher>American Chemical Society (ACS)</publisher>, <volume>11</volume>, <page>3425–3428</page>. https://doi.org/<DOI>10.1021/acsnano.7b02607</DOI>."
10.2143/re.43.0.2011267,3,277,<author><family>BOLSHAKOV</family> <given>AO</given></author>. <issued><year>1992</year></issued>. <title>The Earliest Known Gold Pharaonic Coin</title>. <container-title>Revue d’Égyptologie</container-title> <volume>43</volume>:<page>3–9</page>.
10.1080/10510976009362537,3,643,"<author><family>Rarig</family>, <given>FM</given></author>. <title>Reflections from the retired: Number five</title>. <container-title>Central States Speech Journal</container-title> <issued><year>1960</year></issued>; <volume>11</volume>: <page>123–125</page>. "
10.1002/j.1551-8833.2007.tb08042.x,3,319,"<author><family>Davis</family>, <given>Jim</given></author> (<issued><year>2007</year></issued>), <title>“What Is Asset Management and Where Do You Start?,”</title> <container-title>Journal - American Water Works Association</container-title> <volume>99</volume> (<issue>10</issue>) (<issued><month>October</month></issued>): <page>26–34</page>. doi:<DOI>10.1002/j.1551-8833.2007.tb08042.x</DOI>. <URL>http://dx.doi.org/10.1002/j.1551-8833.2007.tb08042.x</URL>."
10.1007/978-3-642-83584-1_24,7,460,"<author><family>Hitzel</family> <given>SM</given>, <family>Wagner</family> <given>B</given></author>. <title>Computations Relating to the Vortex Flow Experiment</title>. In: <container-title>Symposium Transsonicum III</container-title>. <publisher>Springer Berlin Heidelberg</publisher>; <issued><year>1989</year></issued>. pp. <page>291–303</page>. Available at: <URL>http://dx.doi.org/10.1007/978-3-642-83584-1_24</URL>."
10.1093/mind/xxii.1.149,3,566,"<container-title>Mind</container-title> (<issued><year>1913</year></issued>), <title>JOURNAL OF PHILOSOPHY, PSYCHOLOGY AXD SCIENTIFIC METHODS</title>. , <volume>XXII</volume>(<issue>1</issue>): <page>149–150</page>. available at <URL>http://dx.doi.org/10.1093/mind/xxii.1.149</URL> "
10.1037/t52561-000,8,1452,"<author><family>Ritchie</family>, <given>L. David</given>/<family>Fitzpatrick</family>, <given>Mary Anne</given></author> (<issued><year>1990</year></issued>): <title>Revised Family Communication Patterns Scale</title>. <container-title>PsycTESTS Dataset</container-title>, <publisher>American Psychological Association (APA)</publisher>."
10.1159/000079780,7,1478,"<author><family>Borer</family>, <given>J.S.</given>, <given>S.L.</given> <family>Truter</family>, <given>A.</given> <family>Gupta</family>, <given>E.M.</given> <family>Herrold</family>, <given>J.N.</given> <family>Carter</family>, <given>E.</given> <family>Lee</family>, and <given>L.</given> <family>Pitlor</family></author>. <title>“Heart Failure in Aortic Regurgitation: The Role of Primary Fibrosis and Its Cellular and Molecular Pathophysiology .”</title> In <container-title>Pathophysiology, Evaluation and Management of Valvular Heart Diseases, Vol. 2</container-title>, <page>16–24</page>. <publisher>KARGER</publisher>, <issued><year>2004</year></issued>. Accessed doi:<DOI>10.1159/000079780</DOI>."
10.3109/10425170109042048,3,759,"<author><family>Morlon-Guyot</family>, <given>J.</given>, <family>Mucciolo-Roux</family>, <given>F.</given>, <family>Sanoja</family>, <given>R.R.</given>, & <family>Guyot</family>, <given>J.-P.</given></author> (<issued><year>2001</year></issued>) <title>Characterization of the L. manihotivorans α-Amylase Gene</title>. <container-title>DNA Sequence</container-title>, <volume>12</volume>, <page>27–37</page>. "
10.1109/group4.2016.7739062,22,671,"<author><family>Lamant</family> <given>G.</given>, <family>Flueckiger</family> <given>J.</given>, <family>Villa</family> <given>F.</given>, <family>Farsaei</family> <given>A.</given>, <family>Wang</family> <given>B.</given>, <family>Stoffer</family> <given>R.</given>, <family>Wang</family> <given>X.</given>, <family>Pond</family> <given>J.</given>, <family>Korthorst</family> <given>T.</given></author>: <title>Schematic driven simulation and layout of complex photonic IC’s</title> <container-title>2016 IEEE 13th International Conference on Group IV Photonics (GFP)</container-title>. <publisher>IEEE</publisher> <issued>(<year>2016</year>)</issued>"
10.1111/j.1095-9270.1995.tb00725.x,3,144,"<author><family>Roberts</family>, <given>O.T.P.</given></author>, (<issued><year>1995</year></issued>) <title>The Brigg ‘raft’: a flat-bottomed boat. A response</title>. <container-title>International Journal of Nautical Archaeology</container-title> <volume>24</volume>, <page>159–160</page>."
10.1159/000186421,3,292,"<author><family>Emmerson</family>, <given>B. T.</given></author> <container-title>Nephron</container-title> <issued><year>1991</year></issued>, <volume>58</volume>, <page>233–234</page>."
10.1080/03602558908048581,3,1562,"<title>Editorial board page for “Polymer-Plastics Technology and Engineering”, Volume 28, Number 1</title> (<container-title>Polymer-Plastics Technology and Engineering</container-title>, <volume>28</volume>, <issued><year>1989</year></issued>, <page>a-a</page>)"
10.1002/eji.200535538,3,875,"<author><given>U.</given> <family>Sahin</family>, <given>Ö.</given> <family>Türeci</family>, <given>C.</given> <family>Graf</family>, <given>R.G.</given> <family>Meyer</family>, <given>V.</given> <family>Lennerz</family>, <given>C.M.</given> <family>Britten</family>, <given>C.</given> <family>Dumrese</family>, <given>E.</given> <family>Scandella</family>, <given>T.</given> <family>Wölfel</family> and <given>B.</given> <family>Ludewig</family></author>, <title>“Rapid molecular dissection of viral and bacterial immunomes”</title>, <container-title>Eur. J. Immunol.</container-title> <volume>36</volume> (<issued><year>2006</year></issued>) <page>1049–1057</page>"
10.1016/0022-328x(93)83140-q,3,729,"<author><family>HASSLER</family>, <given>K.</given> and <family>BAUER</family>, <given>G.</given></author>. <title>29Si-Kernresonanzspektren und synthese von bromdisilanen und ioddisilanen</title>. <container-title>Journal of Organometallic Chemistry</container-title> [en ligne]. <issued><month>November</month> <year>1993</year></issued>. Vol. <volume>460</volume>, n° <issue>2</issue>, pp. <page>149–153</page>. DOI <DOI>10.1016/0022-328x(93)83140-q</DOI>. Disponible à l’adresse : <URL>http://dx.doi.org/10.1016/0022-328x(93)83140-q</URL>"
10.1103/physrevlett.99.183601,3,916,"<author><family>Khomeriki</family>, <given>R.</given>, <family>Leon</family>, <given>J.</given></author> <title>Driving Light Pulses with Light in Two-Level Media</title>. <container-title>Physical Review Letters</container-title>. <volume>99</volume> (<issue>18</issue>), doi: <DOI>10.1103/physrevlett.99.183601</DOI> (<issued><year>2007</year></issued>)."
10.1021/acsphotonics.8b00943,3,776,"<author><family>Chaudhuri</family> <given>K</given>, <family>Shaltout</family> <given>A</given>, <family>Shah</family> <given>D</given>, et al.</author>. <title>Photonic Spin Hall Effect in Robust Phase Gradient Metasurfaces Utilizing Transition Metal Nitrides</title>. <container-title>ACS Photonics</container-title>. <issued><year>2018</year></issued>;<volume>6</volume>:<page>99-106</page>."
10.1007/978-3-642-27737-5_388-3,7,596,"<author><family>Sahimi</family> <given>M</given></author>. <title>Percolation and Polymer Morphology and Rheology</title>. <container-title>Encyclopedia of Complexity and Systems Science</container-title>, <publisher>Springer New York</publisher>; <issued><year>2013</year></issued>, p. <page>1–32</page>."
10.1016/s0372-5545(17)43416-x,3,744,"<author><family>Hoban</family> <given>JG</given></author> (<issued><year>1926</year></issued>) <title>“Garget.”</title>. <container-title>The Veterinary Journal (1900)</container-title> <volume>82</volume>, <page>309–311</page>"
10.6009/jjrt.kj00001353111,3,887,"<author><family>Yamaguchi</family>, <given>M.</given>, <family>Taniguchi</family>, <given>Y.</given> & <family>Hayashi</family>, <given>A.</given></author>. <issued><year>1995</year></issued>. <title>340 Evaluation of Spiral Uneven Artifact in Double Thresholded Shaded Surface Display</title>. <container-title>Japanese Journal of Radiological Technology</container-title>, <volume>51</volume>, <page>1410</page>, doi: <DOI>10.6009/jjrt.kj00001353111</DOI>."
10.1553/anzeiger136s177,3,1399,"<author><family>Moutafidou</family>, <given>A.</given></author>. <issued><year>2011</year></issued>. <title>Von der “aufgeklärten Vaterlandsliebe” zum “privilegierten Patriotismus”: Zur Entwicklung und Veränderung politischer Begriffe im Griechenland des 19. Jahrhunderts</title>. <container-title>Anz. phil-hist</container-title> <volume>136</volume>:<page>177–198</page>. doi:<DOI>10.1553/anzeiger136s177</DOI>"
10.1109/cbi.2014.22,22,1312,"<author><family>Rhodes</family> <given>C</given>, <family>Blewitt</family> <given>W</given>, <family>Sharp</family> <given>C</given>, et al.</author>. <title>Smart Routing: A Novel Application of Collaborative Path-Finding to Smart Parking Systems</title>. <container-title>2014 IEEE 16th Conference on Business Informatics</container-title> [Internet]. <publisher>IEEE</publisher>; <issued><year>2014</year></issued>. Available from: <URL>http://dx.doi.org/10.1109/cbi.2014.22</URL>."
10.1111/j.1095-9270.1995.tb00725.x,3,925,<author><family>Roberts</family> <given>OTP</given></author>: <title>The Brigg ‘raft’: a flat-bottomed boat. A response</title>. <container-title>International Journal of Nautical Archaeology</container-title> <issued>1995</issued>;<volume>24</volume>:<page>159–160</page>. 
10.1021/ma049556n,3,982,"<author><family>Wu</family>, <given>C.</given>, <given>W.</given> <family>Li</family>, & <given>X.X.</given> <family>Zhu</family></author> (<issued><year>2004</year></issued>) <title>Viscoelastic Effect on the Formation of Mesoglobular Phase in Dilute Solutions</title> <container-title>Macromolecules</container-title>, <volume>37</volume>(<issue>13</issue>), pp. <page>4989–92</page>."
10.1002/hlca.19830660848,3,1532,<title>Mitteilungen - Communications</title>. (<issued><year>1983</year></issued>)<container-title>Helv Chim Acta</container-title> <volume>66</volume>(<issue>8</issue>): <page>2785–2786</page>
10.3168/jds.s0022-0302(76)84153-7,3,838,"<author><family>Goodenough</family>, <given>E. R.</given> and <family>Kleyn</family>, <given>D. H.</given></author> (<issued><year>1976</year></issued>), &apos;<title>Qualitative and Quantitative Changes in Carbohydrates During the Manufacture of Yogurt</title>&apos;, <container-title>Journal of Dairy Science</container-title>, <volume>59</volume>:<issue>1</issue>, pp. <page>45–47</page>. https://doi.org/<DOI>10.3168/jds.s0022-0302(76)84153-7</DOI>"
10.1163/2468-1733_shafr_sim290080017,8,524,<title>The Lobby: Jewish Political Power and American Foreign Policy</title>. <container-title>The SHAFR Guide Online</container-title>. doi:<DOI>10.1163/2468-1733_shafr_sim290080017</DOI>.
10.1080/09674845.2015.11666794,3,97,"<author><family>Muhammad</family> <given>S.</given></author>, <issued><year>2015</year></issued>, <title>Renal point-of-care testing: collaboration between biomedical scientists and community pharmacists</title>. <container-title>British Journal of Biomedical Science</container-title> <volume>72</volume>, <page>42–46</page>."
10.1080/03085699908592901,3,1344,<author><family>O’Loughlin</family> <given>T</given></author>. <title>An early thirteenth‐century map in Dublin: A window into the world of Giraldus Cambrensis</title>. <container-title>Imago Mundi</container-title> <issued>1999</issued>;<volume>51</volume>(<issue>1</issue>):<page>24–39</page>.
10.1007/bf01840315,3,475,"<author><family>Shiloh</family>, <given>M.</given> et al.</author>: <title>“Eine Verbesserung der Methode zur Bestimmung und Messung der Kräuselung von Textilfasern,”</title> in: <container-title>Kolloid-Z.u.Z.Polymere</container-title> <volume>184</volume>/<issue>1</issue> (<issued><year>1962</year></issued>), pp. <page>91–91</page>, <URL>http://dx.doi.org/10.1007/bf01840315</URL>."
10.1021/jp811245r,3,688,"<author><family>Duncan</family>, <given>T.V.</given>, <family>Méndez Polanco</family>, <given>M.A.</given>, <family>Kim</family>, <given>Y.</given>, and <family>Park</family>, <given>S.-J.</given></author>, <issued><year>2009</year></issued>, <title>Improving the Quantum Yields of Semiconductor Quantum Dots through Photoenhancement Assisted by Reducing Agents</title>. <container-title>The Journal of Physical Chemistry C</container-title>, <volume>113</volume>, <page>7561–7566</page>. https://doi.org/<DOI>10.1021/jp811245r</DOI>."
10.1007/978-3-642-69552-0_3,7,938,"<author><family>Böbel</family> <given>I</given></author>. <issued><year>1984</year></issued>. <title>Die Empirische Messung Der Durch Marktmacht Verursachten Statischen Wohlfahrtsverluste</title>. <container-title>Wettbewerb und Industriestruktur</container-title>. <publisher>Springer Berlin Heidelberg</publisher>, <page>177–232</page>. DOI: <DOI>10.1007/978-3-642-69552-0_3</DOI>"
10.2995/jacsurg.21.374_3,3,485,"<container-title>The Journal of the Japanese Association for Chest Surgery</container-title> [En ligne]. <issued><year>2007</year></issued>. Vol. <volume>21</volume>, n°<issue>3</issue>, p. <page>374</page>. Disponible sur : < https://doi.org/<DOI>10.2995/jacsurg.21.374_3</DOI> >"
10.1186/1757-1146-6-s1-p10,3,1148,"<author><family>Milne</family>, <given>Tamara</given>, <given>Joseph</given> <family>Rogers</family>, <given>Ewan</given> <family>Kinnear</family>, <given>Helen</given> <family>Martin</family>, et al.</author>. <issued><year>2013</year></issued>. <title>Developing an evidence-based clinical pathway for the assessment, diagnosis and management of acute Charcot neuro-arthropathy</title>. <container-title>Journal of Foot and Ankle Research</container-title> <volume>6</volume>(<issue>S1</issue>). DOI: https://doi.org/<DOI>10.1186/1757-1146-6-s1-p10</DOI>."
10.1108/sd-06-2013-0031,3,941,Anon <issued><year>2013</year></issued>. <title>Surviving a global crisis</title>. <container-title>Strategic Direction</container-title> <volume>29</volume>. <publisher>Emerald</publisher>.<page>6–8</page>. doi:<DOI>10.1108/sd-06-2013-0031</DOI>. <URL>http://dx.doi.org/10.1108/sd-06-2013-0031</URL>.
10.1007/978-1-349-25991-5_4,7,58,"<author><family>Parsons</family> <given>S.D.</given>, <family>Watkins</family> <given>J.</given></author>, <title>Hayek and the Limitations of Knowledge: Philosophical Aspects</title>, In: <container-title>Hayek: Economist and Social Philosopher</container-title>, <publisher>Palgrave Macmillan UK</publisher>, <issued><year>1997</year></issued>, <page>63–93</page>"
10.1016/j.progpolymsci.2007.05.012,3,1065,"<author><family>GUIMARD</family>, <given>Nathalie K.</given>; <family>GOMEZ</family>, <given>Natalia</given>; <family>SCHMIDT</family>, <given>Christine E.</given></author> - <title>Conducting polymers in biomedical engineering</title>. <container-title>Progress in Polymer Science</container-title>. . ISSN <ISSN>0079-6700</ISSN>. <volume>32</volume>:<issue>8–9</issue> (<issued><year>2007</year></issued>) <page>876–921</page>. doi: <DOI>10.1016/j.progpolymsci.2007.05.012</DOI>."
10.3403/30304847,41,841,<title>Portland cement</title>.<URL>http://dx.doi.org/10.3403/30304847</URL>.doi: <DOI>10.3403/30304847</DOI>.
10.1061/(asce)cc.1943-5614.0000293,3,405,<author><family>Jiang</family> <given>T</given> & <family>Teng</family> <given>JG</given></author> (<issued><year>2012</year></issued>) <title>Slenderness Limit for Short FRP-Confined Circular RC Columns</title>. <container-title>Journal of Composites for Construction</container-title> <volume>16</volume>:<page>650–661</page>.
10.1007/978-3-7091-6844-8_10,7,640,"<author><family>Weinstock</family> <given>M</given></author> (<issued><year>1997</year></issued>). <title>Possible role of the cholinergic system and disease models</title>. In: “<container-title>Advances in Research on Neurodegeneration</container-title>.” <publisher>Springer Vienna</publisher>, pp. <page>93–102</page>. - doi: <DOI>10.1007/978-3-7091-6844-8_10</DOI>"
10.1107/s0108767300023588,3,486,"<author><family>NESPOLO</family> <given>M.</given>, <family>FERRARIS</family> <given>G.</given></author>. <title>“Twinning by syngonic, metric and selective merohedry, and their effect on the diffraction pattern.”</title>. <container-title>Acta Cryst Sect A</container-title> [En ligne]. <issued><day>25</day> <month>August</month> <year>2000</year></issued>. Vol. <volume>56</volume>, n°<issue>s1</issue>, p. <page>s153–s153</page>. Disponible sur : < https://doi.org/<DOI>10.1107/s0108767300023588</DOI> >"
10.1002/chin.201627039,3,1037,"<author><family>Jin</family>, <given>S.</given> et al.</author> <container-title>ChemInform</container-title> <volume>47</volume>,  (<issued><year>2016</year></issued>)."
10.1177/003463737707400249,3,329,"<author><family>Coleman</family>, <given>L.</given></author> <issued><year>1977</year></issued>. <title>Book Review: Teaching as a Performing Art</title>. <container-title>Review & Expositor</container-title> <volume>74</volume>:<page>259–259</page>. Available at: <URL>http://dx.doi.org/10.1177/003463737707400249</URL>."
10.4070/kcj.1998.28.7.1112,3,58,"<author><family>Kang</family> <given>J.H.</given>, <family>Kim</family> <given>B.-S.</given>, <family>Lee</family> <given>Y.-W.</given>, <family>Keum</family> <given>D.-G.</given>, <family>Jung</family> <given>H.-W.</given>, <family>Lee</family> <given>H.-S.</given>, et al.</author>, <title>The Acute Effect of Estrogen on Vascular Responses and Plasma Endothelin-1 Level in Postmenopausal Women</title>, <container-title>Korean Circ J</container-title>, <issued><year>1998</year></issued>, <volume>28</volume>, <page>1112</page>"
10.1176/ajp.146.3.390-a,3,682,<author><family>DUNNER</family> <given>DL</given></author>. <issued><year>1989</year></issued>. <title>Depression and Mania</title>. <container-title>American Journal of Psychiatry</container-title>. <publisher>American Psychiatric Publishing</publisher> <volume>146</volume>(<issue>3</issue>): <page>390-a-391</page>. DOI: <DOI>10.1176/ajp.146.3.390-a</DOI>.
10.3390/rs10121943,3,1024,"<author><family>Guccione</family>, <given>Pietro</given>, <given>Michele</given> <family>Scagliola</family>, and <given>Davide</given> <family>Giudici</family></author>. <issued><year>2018</year></issued>. <title>“2D Frequency Domain Fully Focused SAR Processing for High PRF Radar Altimeters.”</title> <container-title>Remote Sensing</container-title> <volume>10</volume>. <publisher>MDPI AG</publisher>: <page>1943</page>."
10.1016/s1474-6670(17)32259-0,3,1094,"<author><family>Henni</family> <given>A.</given>, <given>H.</given> <family>Siguerdidjane</family></author>: <title>An Alternative to Circumvent HJI Computation Difficulty in Nonlinear Robustness Analysis</title>.: <container-title>IFAC Proceedings Volumes</container-title> <volume>37</volume>. <page>707–712</page> (<issued><year>2004</year></issued>)"
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Available from: <URL>http://dx.doi.org/10.1017/cts.2017.31</URL><abstract>&lt;jats:p&rt;OBJECTIVES/SPECIFIC AIMS: This project aims to synthesize an angiogenic decorin mimic (VEGFp-DS-SILY) with varying densities of QK and characterize its angiogenic potential and synergism with VEGF by evaluating (1) endothelial cell (EC) migration and proliferation, (2) EC VEGF receptor activation, (3) EC tubule formation in collagen scaffolds, and (4) angiogenesis from a chick chorioallantoic membrane (CAM assay) growing into the scaffold, reflecting the ability of the collagen scaffold to integrate into existing vasculature. The next main goal is to develop and characterize an MMP-degradable nanoparticle system for controlled release of VEGF. Future work will evaluate in vivo effects of VEGFp-DS-SILY bound to a 3D collagen scaffold on ischemic wound repair in a combined excisional wound/bipedical dorsal skin flap rat model. METHODS/STUDY POPULATION: Peptide hydrazides are conjugated to the free carboxylic acid functional groups on dermatan sulfate using EDC chemistry. We added a 3 amino acid spacer (-Gly-Ser-Gly) to the C-terminus of the established QK sequence before the hydrazide functional group and refer to this modified QK as “VEGFp.” VEGFp, SILY, and &lt;jats:italic&rt;N&lt;/jats:italic&rt;-terminal biotinylated versions were synthesized using standard Fmoc solid-phase peptide synthesis protocols and purified using reverse phase HPLC. Coupling efficiencies of peptides to dermatan sulfate were determined spectroscopically at 280 nm measuring the aromatic residues (Trp or Tyr) using a NanoDrop system. Dermatan sulfate with 1 or 4 VEGFp peptides coupled were termed DSV1 and DSV4, respectively. After further conjugation with SILY, we will blend this VEGFp-DS-SILY with unmodified DS-SILY to a total 10 μM to test increasing densities of VEGFp. To verify that the collagen-binding properties of VEGFp-DS-SILY are not compromised by the addition of VEGFp, we will use a streptavidin-HRP system to detect bound biotinylated VEGFp-DS-SILY on collagen-coated plates by established protocols. DSV1 and DSV4 were tested for their effects on endothelial VEGFR2 phosphorylation using an MSD ELISA-type assay and endothelial proliferation using an MTS assay. Cell migration was monitored using an ORIS assay where cells are grown to confluence around a silicone stopper that is then removed to allow cells to migrate inward. Tubulogenesis was evaluated by examining tubule formation on matrigel. Finally, in vivo angiogenesis will be evaluated using a chorioallantoic membrane assay. For extracellular VEGF release, hollow MMP-degradable thermoresponsive nanoparticles [NIPAM, 5 mol% 2-acrylamido-2-methyl-1-propanesulfonic acid (AMPS), 1% Acrylic Acid (AAc), 2 mol% MMP-degradable peptide diacrylate, and potassium persulfate initiator] will be synthesized around noncross-linked polymer cores. The cores will then be diffused out through the shell by dialysis prior to drug loading. SILY (and some biotinylated SILY for visualization) will be conjugated with EDC chemistry for targeting nanoparticles to collagen. NPs size and zeta-potential will be measured on a Malvern Zetasizer. VEGF will be loaded into NPs by co-incubating a loading solution of 1 µg/mL VEGF with 1 mg of NPs, incubating overnight at 4°C. VEGF loading and release will be measured by ELISA. Biological activity of the released VEGF from particles will be determined on ECs using assays similar to those outlined previously. RESULTS/ANTICIPATED RESULTS: Preliminary data have verified the synthesis and purification of SILY and VEGFp (QK-Gly-Ser-Gly-hydrazide), as well as an &lt;jats:italic&rt;N&lt;/jats:italic&rt;-terminal biotinylated version, through mass spectrometry and reverse-phase HPLC, respectively. For proof-of-concept, we have verified binding of VEGFp to the VEGF receptor 2 using a ForteBio Blitz interferometry instrument. In addition to support based on published reports showing retained bioactivity of QK after conjugation using other spacers, our preliminary data suggests that VEGFp still binds to VEGF receptor 2, albeit with decreased affinity like QK as compared with VEGF. Circular dichroism also shows that VEGFp has retained its α-helical structure necessary for bioactivity; however it appears that it has some uncoiling when conjugated to dermatan sulfate. We hypothesize that varying densities of VEGFp conjugated to the decorin mimetic (DS-SILY) will modulate the degree of angiogenic activity and synergy with VEGF. We determined that we can achieve ~70% VEGFp conjugation completion to dermatan sulfate after 3.5 hours. We have quantified VEGFR2 phosphorylation after 5 minute treatments by using phospho-specific antibodies and an ELISA-type protocol in a mesoscale discovery system. Preliminary data with human umbilical vein endothelial cells shows that VEGFp exhibits synergism with VEGF at levels similar to QK. DSV1 and DSV4 data suggests synergy with VEGF, although free-peptides and engineered compounds alone did not show effects similar to VEGF in the conditions tested. Prelminary data with 30 minute treatments suggests that the peptides and compounds may require longer exposures to induce activation, as they may have slower binding rates. In contrast, prolonged stimulation with VEGF causes a sharp increase in receptor activation, peaking around 10 minutes and decreasing significantly by 30 minutes. Peptides QK and VEGFp both slightly increased proliferation of dermal microvascular endothelial cells (HMVECs) after 60 hours incubation. However, incubation with dermatan sulfate and DSV caused significant cell death after 24 hours in reduced growth factor media, likely due to sequestering of growth factors. It is possible that VEGFp-DS-SILY may better stimulate proliferation since it would be presented as a surface bound proteoglycan mimic, rather than as a soluble factor. HMVECs migrated farther for all treatment groups (10 µM QK, 10 µM VEGFp, 1 µM DSV4, and 10 µM DSV4) than the 10 ng/mL VEGF positive control, although more cells migrated in response to VEGF. This may be accounted at least in part by the more pronounced proliferation induced by VEGF. Migration will also be tested in 3D culture within a collagen gel. We are currently testing a 2D matrigel system for tubulogenesis. We have found that 10 µM DSV4 forms qualitatively more well-defined tubules than the untreated control on reduced growth factor matrigel. However, we were not able to quantify the improved tubule formation and are still troubleshooting the tubule analysis. After seeding ECs and culturing for 4, 8, and 12 hours, cells will be fluorescently stained with anti-CD31 and imaged for 3D tubule formation. CAM assay angiogenesis growing into a collagen scaffold. In brief, fertilized chicken embryos are incubated for 2 days before exposing the CAM. VEGFp-DS-SILY bound to a collagen gel will be placed onto the CAM. Some treatment groups will receive additional VEGF to investigate synergistic effects. Light microscope images of angiogenesis into the collagen gel coated with VEGFp-DS-SILY, taken every day from days 10 to 13, will reflect the ability of the collagen scaffold to integrate into existing vasculature and 3D angiogenic potential of VEGFp-DS-SILY with or without VEGF. We expect that VEGFp-DS-SILY treatment will increase the number of vessels formed on the CAM. Preliminary data using a Fluoraldehyde assay indicates that loading of ~300 ng VEGF per mg of nanoparticles can be achieved. We expect that using an MMP-degradable peptide diacrylate crosslinker will allow nanoparticles to degrade in protease-rich environments like the chronic wound bed and release VEGF. Adjustments to the formulation, such as crosslinker density, may need to be modified to control the rate of VEGF release. DISCUSSION/SIGNIFICANCE OF IMPACT: We expect that our angiogenic decorin mimetic will lead to a novel treatment to accelerate healing of ischemic diabetic foot ulcers, thereby reducing the need for limb amputation and mortality rate of diabetic patients. We anticipate that the diabetes research and regenerative medicine communities will (1) gain a platform for targeted delivery of growth factors, (2) understand the dependence of vascularization within 3D collagen constructs on VEGFp densities and VEGF receptor activation in controlling the degree of angiogenesis, and (3) gain the benefits of controlled angiogenesis in ischemic diabetic wound healing.&lt;/jats:p&rt;</abstract>"
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10.26871/oactiva.v2i1.165,3,729,"<author><family>GUTIERREZ PULLA</family>, <given>Karen</given></author>. <title> RELACIÓN ENTRE LA CARIES Y LOS PRINCIPALES MALESTARES EXPRESADOS POR ESCOLARES DE 6 AÑOS, SAN SEBASTIÁN-CUENCA 2016</title>. <container-title>Odontología Activa Revista Científica</container-title> [en ligne]. <issued><day>7</day> <month>March</month> <year>2018</year></issued>. Vol. <volume>2</volume>, n° <issue>1</issue>, pp. <page>7</page>. DOI <DOI>10.26871/oactiva.v2i1.165</DOI>. Disponible à l’adresse : <URL>http://dx.doi.org/10.26871/oactiva.v2i1.165</URL><abstract>&lt;jats:p&rt;OBJETIVO: El objetivo de este estudio fue relacionar la caries y su impacto en los desempeños diarios en escolares de 6 años de la Parroquia San Sebastián del cantón Cuenca en el año 2016. MATERIALES Y MÉTODOS: La metodología aplicada fue de tipo descriptiva, transversal de campo y observacional. El investigador recibió una calibración previa, se aplicó el índice ceod y una parte del instrumento CHILD-OIDP para evaluar las principales molestias expresadas por los escolares.RESULTADOS: La muestra de 197 escolares pertenecientes a 11 escuelas de la Parroquia San Sebastián fue distribuida por sexos, siendo el 45% de sexo femenino y el 55% de sexo masculino. El promedio total del índice ceod fue de 5,25 +3,60 (alto), las mujeres presentaron un promedio de ceod de 5,08 (+3,33) y los hombres de 5,39 (+3,82). Tras aplicar la condición de caries del instrumento CHILD-OIDP se encontró que el 61% de mujeres y el 52% de hombres sufrieron impactos en sus desempeños diarios. Los desempeños con mayor severidad de impacto fueron el comer con un 20,4% y el lavarse los dientes con un 17,1 %, los niños presentaron al menos un desempeño diario impactado. CONCLUSIÓN: Tras relacionar la caries y su impacto en los desempeños diarios se demostró, que los escolares afectados por caries tienen 1.72 veces más probabilidadesde presentar impactos en sus desempeños diarios y por lo tanto mayor afección en su calidad de vida que aquellos que nopresentaron esta enfermedad.&lt;/jats:p&rt;</abstract>"
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