hiphase

Small variant, structural variant, and short tandem repeat phasing tool for PacBio HiFi reads

https://github.com/pacificbiosciences/hiphase

Science Score: 44.0%

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  • CITATION.cff file
    Found CITATION.cff file
  • codemeta.json file
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  • .zenodo.json file
  • DOI references
    Found 4 DOI reference(s) in README
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  • Scientific vocabulary similarity
    Low similarity (14.6%) to scientific vocabulary

Keywords

hifi pacbio-data phasing short-tandem-repeats structural-variants variants
Last synced: 6 months ago · JSON representation ·

Repository

Small variant, structural variant, and short tandem repeat phasing tool for PacBio HiFi reads

Basic Info
  • Host: GitHub
  • Owner: PacificBiosciences
  • License: other
  • Language: Rust
  • Default Branch: main
  • Homepage:
  • Size: 796 KB
Statistics
  • Stars: 72
  • Watchers: 7
  • Forks: 4
  • Open Issues: 2
  • Releases: 20
Topics
hifi pacbio-data phasing short-tandem-repeats structural-variants variants
Created about 3 years ago · Last pushed 11 months ago
Metadata Files
Readme Changelog License Citation

README.md

HiPhase

A tool for jointly phasing small, structural, and tandem repeat variants for PacBio sequencing data


HiPhase will phase variant calls made from PacBio HiFi datasets. Key features relative to other phasing tools include:

  • Joint phasing of small variants and structural variants
  • Support for multi-allelic variation
  • Creates longer, correct phase blocks relative to the current best practice
  • No downsampling of the data
  • Novel algorithms: dual-mode allele assignment and core A* phasing algorithm
  • Quality of life additions: innate multi-threading, simultaneous haplotagging and statistics generation

Authors: Matt Holt, Chris Saunders

Availability

Documentation

Citation

If you use HiPhase, please cite our publication:

Holt, J. M., Saunders, C. T., Rowell, W. J., Kronenberg, Z., Wenger, A. M., & Eberle, M. (2024). HiPhase: Jointly phasing small, structural, and tandem repeat variants from HiFi sequencing. Bioinformatics, btae042.

Original BioRxiv pre-print:

Holt, J. M., Saunders, C. T., Rowell, W. J., Kronenberg, Z., Wenger, A. M., & Eberle, M. (2023). HiPhase: Jointly phasing small and structural variants from HiFi sequencing. bioRxiv, 2023-05.

Need help?

If you notice any missing features, bugs, or need assistance with analyzing the output of HiPhase, please don't hesitate to open a GitHub issue.

Support information

HiPhase is a pre-release software intended for research use only and not for use in diagnostic procedures. While efforts have been made to ensure that HiPhase lives up to the quality that PacBio strives for, we make no warranty regarding this software.

As HiPhase is not covered by any service level agreement or the like, please do not contact a PacBio Field Applications Scientists or PacBio Customer Service for assistance with any HiPhase release. Please report all issues through GitHub instead. We make no warranty that any such issue will be addressed, to any extent or within any time frame.

DISCLAIMER

THIS WEBSITE AND CONTENT AND ALL SITE-RELATED SERVICES, INCLUDING ANY DATA, ARE PROVIDED "AS IS," WITH ALL FAULTS, WITH NO REPRESENTATIONS OR WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED, INCLUDING, BUT NOT LIMITED TO, ANY WARRANTIES OF MERCHANTABILITY, SATISFACTORY QUALITY, NON-INFRINGEMENT OR FITNESS FOR A PARTICULAR PURPOSE. YOU ASSUME TOTAL RESPONSIBILITY AND RISK FOR YOUR USE OF THIS SITE, ALL SITE-RELATED SERVICES, AND ANY THIRD PARTY WEBSITES OR APPLICATIONS. NO ORAL OR WRITTEN INFORMATION OR ADVICE SHALL CREATE A WARRANTY OF ANY KIND. ANY REFERENCES TO SPECIFIC PRODUCTS OR SERVICES ON THE WEBSITES DO NOT CONSTITUTE OR IMPLY A RECOMMENDATION OR ENDORSEMENT BY PACIFIC BIOSCIENCES.

Owner

  • Name: PacBio
  • Login: PacificBiosciences
  • Kind: organization
  • Email: github@pacb.com
  • Location: Start from the website below!

Citation (CITATION.bib)

@article{holt2024hiphase,
  title={HiPhase: Jointly phasing small, structural, and tandem repeat variants from HiFi sequencing},
  author={Holt, James M and Saunders, Christopher T and Rowell, William J and Kronenberg, Zev and Wenger, Aaron M and Eberle, Michael},
  journal={Bioinformatics},
  pages={btae042},
  year={2024},
  publisher={Oxford University Press}
}

GitHub Events

Total
  • Create event: 2
  • Release event: 1
  • Issues event: 25
  • Watch event: 8
  • Delete event: 1
  • Issue comment event: 63
  • Push event: 3
  • Pull request review event: 1
  • Pull request event: 2
Last Year
  • Create event: 2
  • Release event: 1
  • Issues event: 25
  • Watch event: 8
  • Delete event: 1
  • Issue comment event: 63
  • Push event: 3
  • Pull request review event: 1
  • Pull request event: 2

Issues and Pull Requests

Last synced: 6 months ago

All Time
  • Total issues: 8
  • Total pull requests: 0
  • Average time to close issues: 22 days
  • Average time to close pull requests: N/A
  • Total issue authors: 6
  • Total pull request authors: 0
  • Average comments per issue: 5.38
  • Average comments per pull request: 0
  • Merged pull requests: 0
  • Bot issues: 0
  • Bot pull requests: 0
Past Year
  • Issues: 8
  • Pull requests: 0
  • Average time to close issues: 22 days
  • Average time to close pull requests: N/A
  • Issue authors: 6
  • Pull request authors: 0
  • Average comments per issue: 5.38
  • Average comments per pull request: 0
  • Merged pull requests: 0
  • Bot issues: 0
  • Bot pull requests: 0
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