drugfindr

Repository holding the code for the drugfindR R package

https://github.com/cogdisreslab/drugfindr

Science Score: 36.0%

This score indicates how likely this project is to be science-related based on various indicators:

  • CITATION.cff file
  • codemeta.json file
    Found codemeta.json file
  • .zenodo.json file
    Found .zenodo.json file
  • DOI references
  • Academic publication links
    Links to: zenodo.org
  • Academic email domains
  • Institutional organization owner
  • JOSS paper metadata
  • Scientific vocabulary similarity
    Low similarity (18.2%) to scientific vocabulary

Keywords

bioinformatics bioinformatics-pipeline ilincs r transcriptomics
Last synced: 6 months ago · JSON representation

Repository

Repository holding the code for the drugfindR R package

Basic Info
  • Host: GitHub
  • Owner: CogDisResLab
  • License: gpl-3.0
  • Language: R
  • Default Branch: devel
  • Size: 7.38 MB
Statistics
  • Stars: 8
  • Watchers: 1
  • Forks: 3
  • Open Issues: 19
  • Releases: 41
Topics
bioinformatics bioinformatics-pipeline ilincs r transcriptomics
Created about 5 years ago · Last pushed 6 months ago
Metadata Files
Readme Changelog License Codemeta Zenodo

README.Rmd

---
output: github_document
---



```{r, include = FALSE}
knitr::opts_chunk$set( # nolint: extraction_operator_linter.
    collapse = TRUE,
    comment = "#>",
    fig.path = "man/figures/README-",
    out.width = "100%"
)
```

# drugfindR


[![Lifecycle: experimental](https://img.shields.io/badge/lifecycle-experimental-orange.svg)](https://lifecycle.r-lib.org/articles/stages.html#experimental)

[![Continuous Integration / R Workflows](https://github.com/CogDisResLab/drugfindR/actions/workflows/rworkflows.yml/badge.svg)](https://github.com/CogDisResLab/drugfindR/actions/workflows/rworkflows.yml)
[![latest-version](https://img.shields.io/badge/dynamic/json?url=https%3A%2F%2Fcogdisreslab.r-universe.dev%2Fapi%2Fpackages%2FdrugfindR&query=%24.Version&style=flat&label=latest-release&color=orange)](https://github.com/CogDisResLab/drugfindR/releases/latest)
[![license](https://img.shields.io/github/license/CogDisResLab/drugfindR)](https://github.com/CogDisResLab/drugfindR/blob/main/LICENSE)
[![DOI](https://zenodo.org/badge/338354715.svg)](https://zenodo.org/badge/latestdoi/338354715)
[![Codecov test coverage](https://codecov.io/gh/CogDisResLab/drugfindR/branch/devel/graph/badge.svg)](https://app.codecov.io/gh/CogDisResLab/drugfindR?branch=devel)


drugfindR allows convenient access to the iLINCS Gene Knockdown, Gene Overexpression and Chemical Perturbagen databases and allows you to generate and investigate signatures to identify relevant genes and drugs.

## Installation

You can install the released version of drugfindR from [r-universe](https://cogdisreslab.r-universe.dev/drugfindR) with:

```{r, eval = FALSE}
install.packages("drugfindR",
    repos = c(
        "https://cogdisreslab.r-universe.dev",
        "https://cran.r-project.org"
    )
)
```

And the development version from [GitHub](https://github.com/) with:

```{r, eval = FALSE}
if (!requireNamespace("devtools", quietly = TRUE)) {
    install.packages("devtools")
}
devtools::install_github("CogDisResLab/drugfindR")
```

## Usage

This package has two different interfaces that can be used to generate the results:

1. The first way is to use the individual building block functions to generate results.
This is useful if you want to use the results in your own analysis pipeline or want more
control over the results.

2. The second way is to use one of the convenience functions (`investigateSignatures` or `investigateTarget`)
to generate results.
This approach uses the building block functions under the hood with sensible defaults and
returns a final result that can be used for further analysis.

Owner

  • Name: Cognitive Disorders Research Lab
  • Login: CogDisResLab
  • Kind: organization
  • Email: contact@cdrl-ut.org
  • Location: United States of America

CodeMeta (codemeta.json)

{
  "@context": "https://doi.org/10.5063/schema/codemeta-2.0",
  "@type": "SoftwareSourceCode",
  "identifier": "drugfindR",
  "description": "This package provides a convenient way to access the LINCS Signatures available in the iLINCS database. These signatures include Consensus Gene Knockdown Signatures, Gene Overexpression signatures and Chemical Perturbagen Signatures. It also provides a way to enter your own transcriptomic signatures and identify concordant and discordant signatures in the LINCS database.",
  "name": "drugfindR: Investigate iLINCS for candidate repurposable drugs",
  "codeRepository": "https://github.com/CogDisResLab/drugfindR",
  "issueTracker": "https://github.com/CogDisResLab/drugfindR/issues",
  "license": "https://spdx.org/licenses/GPL-3.0",
  "version": "0.99.1055",
  "programmingLanguage": {
    "@type": "ComputerLanguage",
    "name": "R",
    "url": "https://r-project.org"
  },
  "runtimePlatform": "R version 4.5.0 (2025-04-11)",
  "author": [
    {
      "@type": "Person",
      "givenName": [
        "Ali",
        "Sajid"
      ],
      "familyName": "Imami",
      "email": "Ali.Sajid.Imami@gmail.com",
      "@id": "https://orcid.org/0000-0003-3684-3539"
    },
    {
      "@type": "Person",
      "givenName": "Smita",
      "familyName": "Sahay",
      "email": "Smita.Sahay@rockets.utoledo.edu",
      "@id": "https://orcid.org/0009-0003-4377-8963"
    },
    {
      "@type": "Person",
      "givenName": [
        "Justin",
        "Fortune"
      ],
      "familyName": "Creeden",
      "email": "Justin.Creeden@rockets.utoledo.edu",
      "@id": "https://orcid.org/0000-0003-3123-8401"
    }
  ],
  "contributor": [
    {
      "@type": "Person",
      "givenName": [
        "Robert",
        "Erne"
      ],
      "familyName": "McCullumsmith",
      "email": "Robert.McCullumsmith@utoledo.edu",
      "@id": "https://orcid.org/0000-0001-6921-7150"
    }
  ],
  "funder": [
    {
      "@type": "Person",
      "givenName": [
        "Robert",
        "Erne"
      ],
      "familyName": "McCullumsmith",
      "email": "Robert.McCullumsmith@utoledo.edu",
      "@id": "https://orcid.org/0000-0001-6921-7150"
    }
  ],
  "maintainer": [
    {
      "@type": "Person",
      "givenName": [
        "Ali",
        "Sajid"
      ],
      "familyName": "Imami",
      "email": "Ali.Sajid.Imami@gmail.com",
      "@id": "https://orcid.org/0000-0003-3684-3539"
    }
  ],
  "softwareSuggestions": [
    {
      "@type": "SoftwareApplication",
      "identifier": "AnnotationDbi",
      "name": "AnnotationDbi",
      "provider": {
        "@id": "https://www.bioconductor.org",
        "@type": "Organization",
        "name": "Bioconductor",
        "url": "https://www.bioconductor.org"
      },
      "sameAs": "https://bioconductor.org/packages/release/bioc/html/AnnotationDbi.html"
    },
    {
      "@type": "SoftwareApplication",
      "identifier": "BiocStyle",
      "name": "BiocStyle",
      "provider": {
        "@id": "https://www.bioconductor.org",
        "@type": "Organization",
        "name": "Bioconductor",
        "url": "https://www.bioconductor.org"
      },
      "sameAs": "https://bioconductor.org/packages/release/bioc/html/BiocStyle.html"
    },
    {
      "@type": "SoftwareApplication",
      "identifier": "biocthis",
      "name": "biocthis",
      "provider": {
        "@id": "https://www.bioconductor.org",
        "@type": "Organization",
        "name": "Bioconductor",
        "url": "https://www.bioconductor.org"
      },
      "sameAs": "https://bioconductor.org/packages/release/bioc/html/biocthis.html"
    },
    {
      "@type": "SoftwareApplication",
      "identifier": "codemetar",
      "name": "codemetar",
      "provider": {
        "@id": "https://cran.r-project.org",
        "@type": "Organization",
        "name": "Comprehensive R Archive Network (CRAN)",
        "url": "https://cran.r-project.org"
      },
      "sameAs": "https://CRAN.R-project.org/package=codemetar"
    },
    {
      "@type": "SoftwareApplication",
      "identifier": "devtools",
      "name": "devtools",
      "provider": {
        "@id": "https://cran.r-project.org",
        "@type": "Organization",
        "name": "Comprehensive R Archive Network (CRAN)",
        "url": "https://cran.r-project.org"
      },
      "sameAs": "https://CRAN.R-project.org/package=devtools"
    },
    {
      "@type": "SoftwareApplication",
      "identifier": "knitr",
      "name": "knitr",
      "provider": {
        "@id": "https://cran.r-project.org",
        "@type": "Organization",
        "name": "Comprehensive R Archive Network (CRAN)",
        "url": "https://cran.r-project.org"
      },
      "sameAs": "https://CRAN.R-project.org/package=knitr"
    },
    {
      "@type": "SoftwareApplication",
      "identifier": "rmarkdown",
      "name": "rmarkdown",
      "provider": {
        "@id": "https://cran.r-project.org",
        "@type": "Organization",
        "name": "Comprehensive R Archive Network (CRAN)",
        "url": "https://cran.r-project.org"
      },
      "sameAs": "https://CRAN.R-project.org/package=rmarkdown"
    },
    {
      "@type": "SoftwareApplication",
      "identifier": "testthat",
      "name": "testthat",
      "version": ">= 3.0.0",
      "provider": {
        "@id": "https://cran.r-project.org",
        "@type": "Organization",
        "name": "Comprehensive R Archive Network (CRAN)",
        "url": "https://cran.r-project.org"
      },
      "sameAs": "https://CRAN.R-project.org/package=testthat"
    },
    {
      "@type": "SoftwareApplication",
      "identifier": "tidyverse",
      "name": "tidyverse",
      "provider": {
        "@id": "https://cran.r-project.org",
        "@type": "Organization",
        "name": "Comprehensive R Archive Network (CRAN)",
        "url": "https://cran.r-project.org"
      },
      "sameAs": "https://CRAN.R-project.org/package=tidyverse"
    },
    {
      "@type": "SoftwareApplication",
      "identifier": "usethis",
      "name": "usethis",
      "provider": {
        "@id": "https://cran.r-project.org",
        "@type": "Organization",
        "name": "Comprehensive R Archive Network (CRAN)",
        "url": "https://cran.r-project.org"
      },
      "sameAs": "https://CRAN.R-project.org/package=usethis"
    },
    {
      "@type": "SoftwareApplication",
      "identifier": "vcr",
      "name": "vcr",
      "version": ">= 0.6.0",
      "provider": {
        "@id": "https://cran.r-project.org",
        "@type": "Organization",
        "name": "Comprehensive R Archive Network (CRAN)",
        "url": "https://cran.r-project.org"
      },
      "sameAs": "https://CRAN.R-project.org/package=vcr"
    },
    {
      "@type": "SoftwareApplication",
      "identifier": "webmockr",
      "name": "webmockr",
      "provider": {
        "@id": "https://cran.r-project.org",
        "@type": "Organization",
        "name": "Comprehensive R Archive Network (CRAN)",
        "url": "https://cran.r-project.org"
      },
      "sameAs": "https://CRAN.R-project.org/package=webmockr"
    }
  ],
  "softwareRequirements": {
    "1": {
      "@type": "SoftwareApplication",
      "identifier": "magrittr",
      "name": "magrittr",
      "provider": {
        "@id": "https://cran.r-project.org",
        "@type": "Organization",
        "name": "Comprehensive R Archive Network (CRAN)",
        "url": "https://cran.r-project.org"
      },
      "sameAs": "https://CRAN.R-project.org/package=magrittr"
    },
    "2": {
      "@type": "SoftwareApplication",
      "identifier": "tibble",
      "name": "tibble",
      "provider": {
        "@id": "https://cran.r-project.org",
        "@type": "Organization",
        "name": "Comprehensive R Archive Network (CRAN)",
        "url": "https://cran.r-project.org"
      },
      "sameAs": "https://CRAN.R-project.org/package=tibble"
    },
    "3": {
      "@type": "SoftwareApplication",
      "identifier": "rlang",
      "name": "rlang",
      "provider": {
        "@id": "https://cran.r-project.org",
        "@type": "Organization",
        "name": "Comprehensive R Archive Network (CRAN)",
        "url": "https://cran.r-project.org"
      },
      "sameAs": "https://CRAN.R-project.org/package=rlang"
    },
    "4": {
      "@type": "SoftwareApplication",
      "identifier": "dplyr",
      "name": "dplyr",
      "provider": {
        "@id": "https://cran.r-project.org",
        "@type": "Organization",
        "name": "Comprehensive R Archive Network (CRAN)",
        "url": "https://cran.r-project.org"
      },
      "sameAs": "https://CRAN.R-project.org/package=dplyr"
    },
    "5": {
      "@type": "SoftwareApplication",
      "identifier": "purrr",
      "name": "purrr",
      "provider": {
        "@id": "https://cran.r-project.org",
        "@type": "Organization",
        "name": "Comprehensive R Archive Network (CRAN)",
        "url": "https://cran.r-project.org"
      },
      "sameAs": "https://CRAN.R-project.org/package=purrr"
    },
    "6": {
      "@type": "SoftwareApplication",
      "identifier": "readr",
      "name": "readr",
      "provider": {
        "@id": "https://cran.r-project.org",
        "@type": "Organization",
        "name": "Comprehensive R Archive Network (CRAN)",
        "url": "https://cran.r-project.org"
      },
      "sameAs": "https://CRAN.R-project.org/package=readr"
    },
    "7": {
      "@type": "SoftwareApplication",
      "identifier": "stringr",
      "name": "stringr",
      "provider": {
        "@id": "https://cran.r-project.org",
        "@type": "Organization",
        "name": "Comprehensive R Archive Network (CRAN)",
        "url": "https://cran.r-project.org"
      },
      "sameAs": "https://CRAN.R-project.org/package=stringr"
    },
    "8": {
      "@type": "SoftwareApplication",
      "identifier": "stats",
      "name": "stats"
    },
    "9": {
      "@type": "SoftwareApplication",
      "identifier": "lifecycle",
      "name": "lifecycle",
      "provider": {
        "@id": "https://cran.r-project.org",
        "@type": "Organization",
        "name": "Comprehensive R Archive Network (CRAN)",
        "url": "https://cran.r-project.org"
      },
      "sameAs": "https://CRAN.R-project.org/package=lifecycle"
    },
    "10": {
      "@type": "SoftwareApplication",
      "identifier": "S4Vectors",
      "name": "S4Vectors",
      "provider": {
        "@id": "https://www.bioconductor.org",
        "@type": "Organization",
        "name": "Bioconductor",
        "url": "https://www.bioconductor.org"
      },
      "sameAs": "https://bioconductor.org/packages/release/bioc/html/S4Vectors.html"
    },
    "11": {
      "@type": "SoftwareApplication",
      "identifier": "httr2",
      "name": "httr2",
      "provider": {
        "@id": "https://cran.r-project.org",
        "@type": "Organization",
        "name": "Comprehensive R Archive Network (CRAN)",
        "url": "https://cran.r-project.org"
      },
      "sameAs": "https://CRAN.R-project.org/package=httr2"
    },
    "12": {
      "@type": "SoftwareApplication",
      "identifier": "curl",
      "name": "curl",
      "provider": {
        "@id": "https://cran.r-project.org",
        "@type": "Organization",
        "name": "Comprehensive R Archive Network (CRAN)",
        "url": "https://cran.r-project.org"
      },
      "sameAs": "https://CRAN.R-project.org/package=curl"
    },
    "13": {
      "@type": "SoftwareApplication",
      "identifier": "R",
      "name": "R",
      "version": ">= 4.4.0"
    },
    "SystemRequirements": null
  },
  "applicationCategory": "Genomics",
  "isPartOf": "https://bioconductor.org",
  "keywords": [
    "LINCS",
    "iLINCS",
    "drugrepurposing",
    "drugdiscovery",
    "transcriptomics",
    "geneexpression",
    "geneknockdown",
    "geneoverexpression",
    "chemicalperturbagen",
    "drugfindR",
    "r",
    "ilincs",
    "bioinformatics",
    "bioinformatics-pipeline"
  ],
  "fileSize": "2098.301KB",
  "releaseNotes": "https://github.com/CogDisResLab/drugfindR/blob/master/NEWS.md",
  "readme": "https://github.com/CogDisResLab/drugfindR/blob/devel/README.md",
  "contIntegration": [
    "https://github.com/CogDisResLab/drugfindR/actions/workflows/rworkflows.yml",
    "https://app.codecov.io/gh/CogDisResLab/drugfindR?branch=devel"
  ],
  "developmentStatus": "https://lifecycle.r-lib.org/articles/stages.html#experimental"
}

GitHub Events

Total
  • Create event: 51
  • Issues event: 1
  • Release event: 12
  • Watch event: 1
  • Delete event: 25
  • Issue comment event: 94
  • Push event: 57
  • Pull request review event: 2
  • Pull request event: 73
Last Year
  • Create event: 51
  • Issues event: 1
  • Release event: 12
  • Watch event: 1
  • Delete event: 25
  • Issue comment event: 94
  • Push event: 57
  • Pull request review event: 2
  • Pull request event: 73

Issues and Pull Requests

Last synced: 6 months ago

All Time
  • Total issues: 23
  • Total pull requests: 51
  • Average time to close issues: 9 months
  • Average time to close pull requests: 2 days
  • Total issue authors: 4
  • Total pull request authors: 3
  • Average comments per issue: 0.22
  • Average comments per pull request: 1.24
  • Merged pull requests: 35
  • Bot issues: 0
  • Bot pull requests: 14
Past Year
  • Issues: 1
  • Pull requests: 34
  • Average time to close issues: N/A
  • Average time to close pull requests: about 1 hour
  • Issue authors: 1
  • Pull request authors: 2
  • Average comments per issue: 0.0
  • Average comments per pull request: 1.68
  • Merged pull requests: 23
  • Bot issues: 0
  • Bot pull requests: 11
Top Authors
Issue Authors
  • AliSajid (25)
  • willgryan (2)
  • cventophd (1)
  • evelynb4565 (1)
  • renovate[bot] (1)
Pull Request Authors
  • AliSajid (66)
  • renovate[bot] (46)
  • pre-commit-ci[bot] (2)
Top Labels
Issue Labels
bioconductor (12) documentation (7) enhancement (6) good first issue (5) help wanted (4) dependencies (1) renovate (1)
Pull Request Labels
dependencies (43) renovate (43) merge-queue (10)

Dependencies

DESCRIPTION cran
  • R >= 2.10 depends
  • dplyr * imports
  • httr * imports
  • magrittr * imports
  • purrr * imports
  • readr * imports
  • rlang * imports
  • stringr * imports
  • tibble * imports
  • tidyr * imports
  • testthat >= 3.0.0 suggests
.github/workflows/rworkflows.yml actions
  • neurogenomics/rworkflows master composite
.github/workflows/test-coverage.yaml actions
  • actions/checkout v3 composite
  • actions/upload-artifact v3 composite
  • r-lib/actions/setup-r v2 composite
  • r-lib/actions/setup-r-dependencies v2 composite