Description

This repository contains data documentation and code for the analysis in the manuscript titled "Prevalence and Duration of Potential Drug-Drug Interactions Among US Nursing Home Residents, 2018-2020."

Repository Contents

• data_documentation/ - Contains files describing the data sources, key variables, and steps to identify drug-drug interaction (DDI) exposure among beneficiaries in the primary and stability analysis.
• code/ - The programs used for data management and analysis.
• LICENSE - The license under which this repository is shared.
• citation.cff - Citation for the repository.
• README.md - This file, providing an overview of the repository.

Data Documentation

The data_documentation/ directory contains the following files: - Data_Documentation.xlsx - Contains the list of input datasets and years of data used in the analysis; steps to identify DDI exposure among beneficiaries in the primary and stability analysis; description of key variables in source datasets and some derived datasets. - DDIs_List.xlsx - Includes the names of drugs to be included for each potential drug-drug interaction.

Code

The code/ directory contains the following programs: - 0_Create_Dispensing_Datasets.sas - Creating drug-level claims datasets for each drug-drug interaction component. - 1a_Create_Med_Eps.sas - Creating medication use episodes for the drugs associated with each potential drug-drug interaction. - 1b_Create_Med_Eps_Stability.sas - Creating medication use episodes for the stability analysis. - 2a_Create_Concurrent_Med_Eps.sas - Creating episodes of medication use overlap (i.e., concurrent use) for the drugs associated with each potential drug-drug interaction. - 2b_Create_Concurrent_Med_Eps_Stability.sas - Creating episodes of medication use overlap (i.e., concurrent use) in the stability analysis. - 3a_Create_DDI_Exposure_Eps.sas - Creating continuous episodes of exposure for each potential drug-drug interaction. - 3b_Create_DDI_Exposure_Eps_Stability.sas - Creating continuous episodes of exposure for each potential drug-drug interaction in the stability analysis. - 4_Table2.sas - Generating output for Table 2: Top 12 Potential Drug-Drug Interactions Among Nursing Home Residents, 2018-2020 (N = 485,251 Residents). - 5_TableS2-S4.sas - Generating output for the following tables: - Table S2: Potential Drug-Drug Interactions Among Nursing Home Residents Identified by Anrys et al., 2018-2020. - Table S3: Potential Drug-Drug Interactions Among Nursing Home Residents Identified by the 2023 AGS Beers Criteria®, 2018-2020. - Table S4: Potential Drug-Drug Interactions Among Nursing Home Residents Identified by Capiau et al., 2018-2020. - 6_TableS5-S6.sas - Generating output for the following tables: - Table S5: Top 50 Individual Drug Combinations Under “Concomitant Use of At Least CNS-Active Drugs” (Anrys et al.). - Table S6: Top 50 Individual Drug Combinations Under “Any Combination of At Least CNS-Active Drugs” (2023 AGS Beers Criteria®).

Programs were run in sequence to produce the study findings. Cohort creation programs and programs used to produce Table 1 have not been included; a broad description of these steps can be found in the manuscript.

Additional information (and code) for identifying nursing home time with observable Part D prescription drug data can be found in the upcoming publication from Harris et al. "Identifying observable medication use time in administrative databases: A tutorial using nursing home residents" (doi.org/10.5281/zenodo.15012812).