decitabine-treatment

A multiomics approach reveals RNA dynamics promote cellular sensitivity to DNA hypomethylation

https://github.com/gilbertlabucsf/decitabine-treatment

Science Score: 36.0%

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    Links to: ncbi.nlm.nih.gov, nature.com
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Keywords

bioinformatics dna-methylation drug-discovery rna-modifications
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A multiomics approach reveals RNA dynamics promote cellular sensitivity to DNA hypomethylation

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bioinformatics dna-methylation drug-discovery rna-modifications
Created about 5 years ago · Last pushed over 1 year ago
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README.md

A multiomics approach reveals RNA dynamics promote cellular sensitivity to DNA hypomethylation

This repository contains all the scripts necessary for producing the results of the manuscript:

DOI: 10.1038/s41598-024-77314-9

Raw data is also available at:

GEO:GSE222886


List of reproducible pipelines and other repositories developed as part of this project: - Differential gene expression analysis: The Salmon-tximport-DESeq2 pipeline - Differential RNA stability analysis: The STAR-featureCounts-REMBRANDTS-limma pipeline - Integrated methods for meRIP-seq data analysis https://github.com/abearab/imRIP - Pathway analysis using PAGE algorithm and downstream analysis https://github.com/abearab/pager - Scripts for mapping NGS reads to HERVs https://github.com/abearab/HERVs


This repo has been developed in Gilbert at UCSF and Arc Institute by Abolfazl Arab, in collaboration with Goodarzi lab at UCSF. This also incldue some original/revised codes from Alex Y. Ge, Hosseinali Asgharian, and Hani Goodarzi.

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  • Name: GILBERT LAB
  • Login: GilbertLabUCSF
  • Kind: organization

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