Trends in CD4 and viral load testing over time.

This repository shares the Stata coding files used to produce the output published in the following:

CROI 2019 conference abstract

Zaniewski E, Ostinelli CHD, Maxwell N, Euvrard J, Van Dijk JH, Bosomprah S, Tanser F, Fox MP, Sipambo N, Muhairwe J, Egger M. Trends in CD4 and viral load testing in southern Africa: Analysis of six countries. CROI abstract.

JIAS 2020 manuscript

Zaniewski E, Dao Ostinelli CH, Chammartin F, Maxwell N, Davies MA, Euvrard J, et al. Trends in CD4 and viral load testing 2005 to 2018: multi-cohort study of people living with HIV in Southern Africa. J Int AIDS Soc. 2020 Jul;23(7):e25546. doi: 10.1002/jia2.25546. doi: 10.1002/jia2.25546

This analysis included HIV cohort data from The International epidemiology Databases to Evaluate AIDS Southern Africa collaboration (https://www.iedea-sa.org), which collects de-identified patient-level data from participating cohorts in Lesotho, Malawi, Mozambique, South Africa, Zambia and Zimbabwe.

Methods

We assessed the number of CD4 cell count and VL tests performed by exact calendar date from 1 January 2005 to 31 December 2018, irrespective of whether testing occurred before or after ART start, and calculated the ratio of CD4 cell count to VL testing per year over time and stratified by country. We examined the percentage of adults with a CD4 cell count at ART start, the percentage of adults with any CD4 cell count up to six months before ART start, and, among those with a CD4 cell count, the percentage of adults starting ART with advance HIV disease by country and calendar year. We defined ART as a regimen of at least three antiretroviral drugs from two drug classes, and advanced HIV disease as a CD4 cell count <200 cells/mm3.

Do files

All statistical analyses were performed using Stata version 15.1 (Stata Corp., College Station, TX, USA).

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License

© 2020 The Authors. Journal of the International AIDS Society published by John Wiley & Sons Ltd on behalf of International AIDS Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

This is an open access article under the CC BY license. https://creativecommons.org/licenses/by/4.0/