BALCONY
R package: BALCONY (Better ALignment CONsensus analYsis)
Science Score: 13.0%
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Low similarity (6.5%) to scientific vocabulary
Keywords
Repository
R package: BALCONY (Better ALignment CONsensus analYsis)
Basic Info
Statistics
- Stars: 3
- Watchers: 2
- Forks: 4
- Open Issues: 5
- Releases: 0
Topics
Metadata Files
README.md
BALCONY
This repository holds the BALCONY R package, which can be downloaded at its CRAN website.
BALCONY (Better ALignment CONsensus analYsis) is an R package that facilitates the evolutionary analysis and the identification of conservation check the variablity of selected amino acids in protein structure. One of the unique functionalities of the BALCONY package concerns the analysis of individual amino acids in primary protein structure and their neighbours in tertiary structure. Residues defining active site cavities, co-factor binding sites, selectivity filters, channels or tunnels are examples of applications for this package. BALCONY is flexible and versatile enough to combine and analyse evolutionary and structural data in a simple and transparent manner.
Conservation analysis can provide insights into rational protein design. Amino acids favoured by evolution are attractive hot spots for mutations prediction. Conversely, the most variable residues may also be great candidates for enzyme property enhancements since theoretically these are not fundamental for protein stability.
Package installation
install.packages("BALCONY")
Publication
See the publication introducing the BALCONY package.
Alicja Płuciennik, Michał Stolarczyk, Maria Bzówka, Agata Raczyńska, Tomasz Magdziarz, and Artur Góra. “BALCONY: An R Package for MSA and Functional Compartments of Protein Variability Analysis.” BMC Bioinformatics 19, no. 1 (August 14, 2018): 300. https://doi.org/10.1186/s12859-018-2294-z.
Owner
- Name: Michal Stolarczyk
- Login: stolarczyk
- Kind: user
- Location: Charlottesville, VA
- Company: NIAID/NIH
- Twitter: m_stolarczyk
- Repositories: 2
- Profile: https://github.com/stolarczyk
software engineer @niaid
GitHub Events
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Last Year
Committers
Last synced: about 2 years ago
Top Committers
| Name | Commits | |
|---|---|---|
| Michał | s****3@g****m | 171 |
| Ptero | a****k@o****m | 28 |
| Ptero | g****d@o****l | 7 |
| Tomasz Magdziarz | t****z@t****l | 2 |
Committer Domains (Top 20 + Academic)
Issues and Pull Requests
Last synced: 6 months ago
All Time
- Total issues: 13
- Total pull requests: 3
- Average time to close issues: 14 days
- Average time to close pull requests: 2 months
- Total issue authors: 5
- Total pull request authors: 2
- Average comments per issue: 0.77
- Average comments per pull request: 0.0
- Merged pull requests: 1
- Bot issues: 0
- Bot pull requests: 0
Past Year
- Issues: 0
- Pull requests: 0
- Average time to close issues: N/A
- Average time to close pull requests: N/A
- Issue authors: 0
- Pull request authors: 0
- Average comments per issue: 0
- Average comments per pull request: 0
- Merged pull requests: 0
- Bot issues: 0
- Bot pull requests: 0
Top Authors
Issue Authors
- stolarczyk (6)
- richelbilderbeek (4)
- ig624 (1)
- apluciennik (1)
- maribzo (1)
Pull Request Authors
- currocam (2)
- tljm (1)
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Dependencies
- Biostrings * imports
- Rpdb * imports
- base * imports
- dplyr * imports
- progress * imports
- readr * imports
- scales * imports
- seqinr * imports
- stats * imports