mddc

MDDC offers methods for detecting signals related to (adverse event, drug) pairs, a data generation function for simulating pharmacovigilance datasets, and various utility functions.

https://github.com/niuniular/mddc

Keywords

pharmacovigilance

Last synced: 10 months ago · JSON representation

Repository

MDDC offers methods for detecting signals related to (adverse event, drug) pairs, a data generation function for simulating pharmacovigilance datasets, and various utility functions.

Basic Info

Host: GitHub
Owner: niuniular
License: gpl-3.0
Language: R
Default Branch: main
Homepage: https://niuniular.github.io/MDDC/
Size: 7.7 MB

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Open Issues: 0
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Topics

pharmacovigilance

Created almost 2 years ago · Last pushed about 1 year ago

Metadata Files

Readme Changelog Contributing License Code of conduct Codemeta

| Category | Badge | |--------------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------| | Usage | | | Release | | | Development | |

Introduction

In this package, we present the Modified Detecting Deviating Cells (MDDC) algorithm for adverse event identification.
For a certain time period, the spontaneous reports can be extracted from the safety database and depicted as an $I \times J$ contingency table, where:
- $I$ denotes the total number of AEs
- $J$ denotes the total number of drugs or vaccines
- With cell counts $n_{ij}$ the total number of reported cases corresponding to the $j$-th drug/vaccine and $i$-th AE
We are interested in which (AE, drug or vaccine) pairs are signals. The signals refer to potential adverse events that may be caused by a drug/vaccine.
In the contingency table setting, the signals refer to the cells with $n_{ij}$ abnormally higher than the expected values.
Rousseeuw and Bossche (2018) proposed the Detecting Deviating Cells (DDC) algorithm for outlier identification in a multivariate dataset.
The original DDC algorithm assumes multivariate normality of the data and selects cutoff values based on this assumption. We modify the DDC algorithm to better suit the discrete nature of adverse event data in pharmacovigilance that clearly do not follow a multivariate normal distribution.
Our Modified Detecting Deviating Cells (MDDC) algorithm has the following characteristics:
1. It is easy to compute.
2. It considers AE relationships.
3. It depends on data-driven cutoffs.
4. It is independent of the use of ontologies.
The MDDC algorithm has five steps, with the first two steps identifying univariate outliers via cutoffs, and the next three steps evaluating the signals via the use of AE correlations. The algorithm can be found at MDDC algorithm.

Authors

Anran Liu Email: anranliu@buffalo.edu
Raktim Mukhopadhyay Email: raktimmu@buffalo.edu
Marianthi Markatou Email: markatou@buffalo.edu

Maintainers

Anran Liu Email: anranliu@buffalo.edu
Raktim Mukhopadhyay Email: raktimmu@buffalo.edu

Documentation

The documentation is hosted at - https://niuniular.github.io/MDDC/index.html

Citation

If you use this package in your research or work, please cite it as follows:

@misc{liu2024mddcrpythonpackage, title={MDDC: An R and Python Package for Adverse Event Identification in Pharmacovigilance Data}, author={Anran Liu and Raktim Mukhopadhyay and Marianthi Markatou}, year={2024}, eprint={2410.01168}, archivePrefix={arXiv}, primaryClass={stat.CO}, url={https://arxiv.org/abs/2410.01168}, }

Funding Information

The work has been supported by Food and Drug Administration, and Kaleida Health Foundation.

References

Liu, A., Mukhopadhyay, R., and Markatou, M. (2024). MDDC: An R and Python package for adverse event identification in pharmacovigilance data. arXiv preprint. arXiv:2410.01168

Liu, A., Markatou, M., Dang, O., and Ball, R. (2024). Pattern discovery in pharmacovigilance through the Modified Detecting Deviating Cells (MDDC) algorithm. Technical Report, Department of Biostatistics, University at Buffalo.

Rousseeuw, P. J., and Bossche, W. V. D. (2018). Detecting deviating data cells. Technometrics, 60(2), 135-145.

Owner

Name: Anran Liu
Login: niuniular
Kind: user

Repositories: 1
Profile: https://github.com/niuniular

CodeMeta (codemeta.json)

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cran.r-project.org: MDDC

Modified Detecting Deviating Cells Algorithm in Pharmacovigilance

Homepage: https://github.com/niuniular/MDDC
Documentation: http://cran.r-project.org/web/packages/MDDC/MDDC.pdf
License: GPL-3
Latest release: 1.1.0
published about 1 year ago

Versions: 2
Dependent Packages: 0
Dependent Repositories: 0
Downloads: 205 Last month

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Dependent packages count: 28.1%

Dependent repos count: 34.6%

Average: 49.8%

Downloads: 86.6%

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anranliu@buffalo.edu

Last synced: 10 months ago

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