simtost

SimTOST is an R package designed to facilitate the sample size estimation for bioequivalence studies using a simulation-based approach.

https://github.com/smartdata-analysis-and-statistics/simtost

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SimTOST is an R package designed to facilitate the sample size estimation for bioequivalence studies using a simulation-based approach.

README.Rmd

---
output: github_document
---



```{r, include = FALSE}
knitr::opts_chunk$set(
  collapse = TRUE,
  comment = "#>",
  fig.path = "man/figures/README-",
  out.width = "100%"
)
```

# SimTOST 


[![R-CMD-check](https://github.com/smartdata-analysis-and-statistics/SimTOST/actions/workflows/R-CMD-check.yml/badge.svg)](https://github.com/smartdata-analysis-and-statistics/SimTOST/actions/workflows/R-CMD-check.yml)
[![CRAN status](https://www.r-pkg.org/badges/version/SimTOST)](https://CRAN.R-project.org/package=SimTOST)
[![metacran downloads](https://cranlogs.r-pkg.org/badges/last-month/SimTOST)](https://cran.r-project.org/package=SimTOST)


`SimTOST` is an R package specifically designed for bioequivalence studies, providing simulation-based sample size estimation for the Two One-Sided Tests (TOST) procedure. It offers flexible options to handle complex study designs, including trials with multiple correlated primary endpoints, multiple hypotheses, and treatment arms. By incorporating correlations between endpoints, `SimTOST` ensures accurate and robust planning of bioequivalence trials, making it a powerful tool for studies with intricate requirements.

## Installation

`SimTOST` is available on CRAN and can be installed by running the following code.

``` r
install.packages("SimTOST")
```

You can also install the development version of SimTOST from [GitHub](https://github.com/) with:

``` r
# install.packages("devtools")
devtools::install_github("smartdata-analysis-and-statistics/SimTOST")
```

## Vignettes

The main features of this package is `sampleSize` function which can be used to calculate sample size for individual and multiple endpoints. Various worked examples are available as [vignettes](https://smartdata-analysis-and-statistics.github.io/SimTOST/), with an introduction provided at [Introduction](https://smartdata-analysis-and-statistics.github.io/SimTOST/articles/intropkg.html).


| **Vignette**                                    | **Design**   | **Number of Arms** | **Number of Endpoints** |
|------------------------------------------------|--------------|---------------------|--------------------------|
| [Bioequivalence Tests for Parallel Trial Designs with Log-Normal Data](https://smartdata-analysis-and-statistics.github.io/SimTOST/articles/sampleSize_parallel.html) | Parallel    | 2                  | Multiple (e.g., 2 or 3)                 |
| [Bioequivalence Tests for 2x2 Cross-Over Trial Designs with Log-Normal Data](https://smartdata-analysis-and-statistics.github.io/SimTOST/articles/sampleSize_crossover.html) | Cross-over    | 2                  | 2                 |
| [Bioequivalence Tests for Parallel Trial Designs: 2 Arms, 1 Endpoint](https://smartdata-analysis-and-statistics.github.io/SimTOST/articles/sampleSize_parallel_2A1E.html) | Parallel    | 2                  | 1                        |
| [Bioequivalence Tests for Parallel Trial Designs: 3 Arms, 1 Endpoint](https://smartdata-analysis-and-statistics.github.io/SimTOST/articles/sampleSize_parallel_3A1E.html) | Parallel    | 3                  | 1                        |
| [Bioequivalence Tests for Parallel Trial Designs: 2 Arms, 3 Endpoints](https://smartdata-analysis-and-statistics.github.io/SimTOST/articles/sampleSize_parallel_2A3E.html)  | Parallel    | 2                  | 3 |
| [Bioequivalence Tests for Parallel Trial Designs: 3 Arms, 3 Endpoints](https://smartdata-analysis-and-statistics.github.io/SimTOST/articles/sampleSize_parallel_3A3E.html)  | Parallel    | 3                  | 3 |

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