Tenta — Peer-reviewed • Rank 3.0 • Science 93%

Tenta: Remote and Real-Time Sensor Network Management - Published in JOSS (2025)

IBCAO_py — Peer-reviewed • Rank 3.0 • Science 93%

IBCAO_py: A matplotlib library for using the International Bathymetric Chart of the Arctic Ocean with cartopy and matplotlib - Published in JOSS (2017)

ultralytics • Rank 31.9 • Science 64%

Ultralytics YOLO 🚀

BluVision Macro - a software for automated powdery mildew and rust disease quantification on detached leaves. — Peer-reviewed • Rank 2.9 • Science 93%

BluVision Macro - a software for automated powdery mildew and rust disease quantification on detached leaves. - Published in JOSS (2020)

simpeg • Rank 18.9 • Science 77%

Simulation and Parameter Estimation in Geophysics - A python package for simulation and gradient based parameter estimation in the context of geophysical applications.

aucmedi • Rank 10.7 • Science 85%

a framework for Automated Classification of Medical Images

feos • Rank 18.6 • Science 77%

FeOs - A Framework for Equations of State and Classical Density Functional Theory

ikpy • Rank 18.6 • Science 77%

IKPy, an Universal Inverse Kinematics library

ccdproc • Rank 18.5 • Science 77%

Astropy affiliated package for reducing optical/IR CCD data

Reel1.0 - A visualization tool for evaluating powder diffraction refinements — Peer-reviewed • Rank 2.5 • Science 93%

Reel1.0 - A visualization tool for evaluating powder diffraction refinements - Published in JOSS (2021)

LightTwinSVM — Peer-reviewed • Rank 2.5 • Science 93%

LightTwinSVM: A Simple and Fast Implementation of Standard Twin Support Vector Machine Classifier - Published in JOSS (2019)

filter-functions • Rank 10.4 • Science 85%

Efficient numerical calculation of generalized filter functions

BrainGlobe Atlas API — Peer-reviewed • Rank 18.2 • Science 77%

BrainGlobe Atlas API: a common interface for neuroanatomical atlases - Published in JOSS (2020)

mikecalsetup — Peer-reviewed • Rank 2.1 • Science 93%

mikecalsetup: an open-source python tool for automatically creating calibration setups of MIKE SHE models in PEST or OSTRICH - Published in JOSS (2023)

LiGuard — Peer-reviewed • Rank 1.9 • Science 93%

LiGuard: Interactively and Rapidly Create Point-Cloud and Image Processing Pipelines - Published in JOSS (2025)

cchdo.hydro • Rank 9.9 • Science 85%

The big ol CCHDO netCDF-CF project

qbraid • Rank 17.9 • Science 77%

A platform-agnostic quantum runtime framework

cooler • Rank 17.7 • Science 77%

A cool place to store your Hi-C

amici • Rank 17.6 • Science 77%

High-performance sensitivity analysis for large ordinary differential equation models

PySWMM — Peer-reviewed • Rank 17.4 • Science 77%

PySWMM: The Python Interface to Stormwater Management Model (SWMM) - Published in JOSS (2020)

gladia-torchaudio • Rank 30.4 • Science 64%

Data manipulation and transformation for audio signal processing, powered by PyTorch

Multivariate Covariance Generalized Linear Models in Python — Peer-reviewed • Rank 1.4 • Science 93%

Multivariate Covariance Generalized Linear Models in Python: The mcglm library - Published in JOSS (2024)

catalystcoop.pudl • Rank 17.3 • Science 77%

The Public Utility Data Liberation Project provides analysis-ready energy system data to climate advocates, researchers, policymakers, and journalists.

bioframe • Rank 17.3 • Science 77%

Genomic interval operations on Pandas DataFrames

pastas • Rank 17.3 • Science 77%

Pastas is an open-source Python framework for the analysis of groundwater time series.

gitlab2prov • Rank 9.1 • Science 85%

🔍️ Extract provenance information (W3C PROV) from GitLab projects.

lenskit • Rank 17.1 • Science 77%

Python recommendation toolkit

pyiron_atomistics • Rank 17.1 • Science 77%

pyiron_atomistics - an integrated development environment (IDE) for atomistic simulation in computational materials science.

DEVSIM — Peer-reviewed • Rank 16.9 • Science 77%

DEVSIM: A TCAD Semiconductor Device Simulator - Published in JOSS (2022)

flaml • Rank 29.9 • Science 64%

A fast library for AutoML and tuning. Join our Discord: https://discord.gg/Cppx2vSPVP.

heat • Rank 16.8 • Science 77%

Distributed tensors and Machine Learning framework with GPU and MPI acceleration in Python

manim-slides • Rank 16.8 • Science 77%

Tool for live presentations using manim

pymrio • Rank 16.8 • Science 77%

Multi-Regional Input-Output Analysis in Python.

hidimstat • Rank 16.6 • Science 77%

Machine learning for NeuroImaging in Python

sncosmo • Rank 16.5 • Science 77%

Python library for supernova cosmology

PARMESAN — Peer-reviewed • Rank 4.4 • Science 89%

PARMESAN: Meteorological Timeseries and Turbulence Analysis Backed by Symbolic Mathematics - Published in JOSS (2024)

bloqade-analog • Rank 16.4 • Science 77%

QuEra's Neutral Atom SDK for Analog QPUs

DMT-core — Peer-reviewed • Rank 4.4 • Science 89%

DMT-core: A Python Toolkit for Semiconductor Device Engineers - Published in JOSS (2022)

scikit-activeml • Rank 16.3 • Science 77%

scikit-activeml: Python library for active learning on top of scikit-learn

matplotlib • Rank 39.1 • Science 54%

matplotlib: plotting with Python

pyiron • Rank 16.0 • Science 77%

pyiron - an integrated development environment (IDE) for computational materials science.

pyprocar • Rank 16.0 • Science 77%

A Python library for electronic structure pre/post-processing

pydantic • Rank 38.9 • Science 54%

Data validation using Python type hints

pytest • Rank 38.9 • Science 54%

The pytest framework makes it easy to write small tests, yet scales to support complex functional testing

decimer • Rank 15.9 • Science 77%

DECIMER Image Transformer is a deep-learning-based tool designed for automated recognition of chemical structure images. Leveraging transformer architectures, the model converts chemical images into SMILES strings, enabling the digitization of chemical data from scanned documents, literature, and patents.

geocat-examples • Rank 7.9 • Science 85%

GeoCAT-examples provides a gallery of visualization examples demonstrating how to reproduce plots from NCL Applications scripts with packages in Python. It also includes some longer form examples demonstrating how to use functionality from various GeoCAT packages.

gensim • Rank 15.8 • Science 77%

Topic Modelling for Humans

black • Rank 38.8 • Science 54%

The uncompromising Python code formatter

pymor • Rank 15.8 • Science 77%

pyMOR - Model Order Reduction with Python

pypartmc • Rank 15.8 • Science 77%

Python (and C++) interface to PartMC with Jupyter/Python, Julia and Matlab examples

plotnine • Rank 28.7 • Science 64%

A Grammar of Graphics for Python

jwst • Rank 20.6 • Science 72%

Python library for science observations from the James Webb Space Telescope

pygama • Rank 15.5 • Science 77%

Python package for data processing and analysis

mpi4py • Rank 25.4 • Science 67%

Python bindings for MPI

kda • Rank 7.4 • Science 85%

Python package used for the analysis of biochemical kinetic diagrams.

hatchet • Rank 7.3 • Science 85%

Graph-indexed Pandas DataFrames for analyzing hierarchical performance data

tts • Rank 28.2 • Science 64%

🐸💬 - a deep learning toolkit for Text-to-Speech, battle-tested in research and production

climpred — Peer-reviewed • Rank 15.2 • Science 77%

climpred: Verification of weather and climate forecasts - Published in JOSS (2021)

imageio • Rank 33.2 • Science 59%

Python library for reading and writing image data

mesa-geo • Rank 15.1 • Science 77%

GIS Extension for Mesa Agent-Based Modeling

jug • Rank 15.0 • Science 77%

Parallel programming with Python

DeepTrees: Tree Crown Segmentation and Analysis in Remote Sensing Imagery with PyTorch • Rank 3.0 • Science 89%

DeepTrees: Tree Crown Segmentation and Analysis in Remote Sensing Imagery with PyTorch - Published in JOSS (2025)

poetry • Rank 37.7 • Science 54%

Python packaging and dependency management made easy

foyer • Rank 14.7 • Science 77%

A package for atom-typing as well as applying and disseminating forcefields

fastapi • Rank 37.7 • Science 54%

FastAPI framework, high performance, easy to learn, fast to code, ready for production

awkward • Rank 14.6 • Science 77%

Manipulate JSON-like data with NumPy-like idioms.

decaylanguage • Rank 14.6 • Science 77%

Package to parse decay files, describe and convert particle decays between digital representations.

kernel-tuner • Rank 14.6 • Science 77%

Kernel Tuner

srai • Rank 14.6 • Science 77%

Spatial Representations for Artificial Intelligence - a Python library toolkit for geospatial machine learning focused on creating embeddings for downstream tasks

pythainlp • Rank 24.6 • Science 67%

Thai natural language processing in Python

mep-django • Rank 6.5 • Science 85%

Shakespeare and Company Project - Python/Django web application

bmi-geotiff • Rank 6.4 • Science 85%

Access data (and metadata) from a GeoTIFF file through a BMI

geniza • Rank 6.3 • Science 85%

version 4.x of the Princeton Geniza Project

linien • Rank 14.3 • Science 77%

Spectroscopy lock application using RedPitaya

rna-tools • Rank 14.2 • Science 77%

🔧rna-tools: a toolbox to analyze sequences, structures and simulations of RNA (and more) used by RNA CASP, RNA PUZZLES, and me ;-) docs @ http://rna-tools.rtfd.io web @ http://rna-tools.online

pygeohydro • Rank 13.9 • Science 77%

A part of HyRiver software stack for accessing hydrology data through web services

ldtk • Rank 13.9 • Science 77%

Python toolkit for calculating stellar limb darkening profiles and model-specific coefficients using the stellar atmosphere spectrum library by Husser et al. (2013). Described in Parviainen & Aigrain, MNRAS 453, 3821–3826 (2015).

georasters • Rank 13.8 • Science 77%

GeoRasters is a Python module that provides a fast and flexible tool to work with GIS raster files.

yt_astro_analysis • Rank 13.7 • Science 77%

yt astrophysical analysis modules

great-tables • Rank 23.7 • Science 67%

Make awesome display tables using Python

openfermion • Rank 13.6 • Science 77%

Python package for compiling and analyzing quantum algorithms to simulate electronic structures.

nltk • Rank 36.5 • Science 54%

NLTK Source

mail-deduplicate • Rank 13.4 • Science 77%

📧 CLI to deduplicate mails from mail boxes

cadquery • Rank 23.4 • Science 67%

A python parametric CAD scripting framework based on OCCT

cheetah-accelerator • Rank 13.3 • Science 77%

Fast and differentiable particle accelerator optics simulation for reinforcement learning and optimisation applications.

vak • Rank 13.3 • Science 77%

A neural network framework for researchers studying acoustic communication

corpus-annotation-graph-builder • Rank 5.2 • Science 85%

Corpus Annotation Graph builder (CAG) is an architectural framework that employs the build-and-annotate pattern for creating a graph.

scri • Rank 13.1 • Science 77%

Python/numba code for manipulating time-dependent functions of spin-weighted spherical harmonics on future null infinity

aguaclara • Rank 13.1 • Science 77%

An open-source Python package for designing and performing research on AguaClara water treatment plants.

scalene • Rank 26.0 • Science 64%

Scalene: a high-performance, high-precision CPU, GPU, and memory profiler for Python with AI-powered optimization proposals

reactionmechanismgenerator • Rank 12.9 • Science 77%

Python version of the amazing Reaction Mechanism Generator (RMG).

pyo3 • Rank 35.8 • Science 54%

Rust bindings for the Python interpreter

astrophot • Rank 12.8 • Science 77%

A fast, flexible, automated, and differentiable astronomical image 2D forward modelling tool for precise parallel multi-wavelength photometry

litstudy • Rank 12.7 • Science 77%

LitStudy: Using the power of Python to automate scientific literature analysis from the comfort of a Jupyter notebook

snakefmt • Rank 22.5 • Science 67%

The uncompromising Snakemake code formatter

statsmodels • Rank 35.5 • Science 54%

Statsmodels: statistical modeling and econometrics in Python

llnl-thicket • Rank 14.4 • Science 75%

conda • Rank 35.3 • Science 54%

A system-level, binary package and environment manager running on all major operating systems and platforms.

tensorwaves • Rank 12.3 • Science 77%

Python fitter package for multiple computational back-ends

mss • Rank 12.3 • Science 77%

A QT application, a OGC web map server, a collaboration server to plan atmospheric research flights.